FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term antiporter activity ID (Ontology) GO:0015297 (Gene Ontology)
Definition Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).[ ISBN:0815340729 PubMed:10839820 ]
Also Known As"countertransporter activity" ; "exchange transporter activity" ; "solute:solute antiporter activity"
Comment
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Full annotation statements 
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 Gene Groups Genes
 antiporter activity (all annotations which use CV term, excluding "NOT" statements)
     enables | antiporter activity       --
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Vocabulary search 
  active transmembrane transporter activity
   |__secondary active transmembrane transporter activity
       |__antiporter activity  55 rec.
           |__(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
           |__acetyl-CoA:CoA antiporter activity
           |__acetylcholine:proton antiporter activity 1 rec.
           |__acridine:proton antiporter activity
           |__agmatine:putrescine antiporter activity
           |__amino acid:monoatomic cation antiporter activity 5 rec.
           |   |__3-sulfino-L-alanine: proton, glutamate antiporter activity 1 rec.
           |   |__gamma-aminobutyric acid:proton antiporter activity 2 rec.
           |   |__glycine:proton antiporter activity
           |   |__L-alanine:proton antiporter activity
           |   |__L-asparagine, sodium:proton antiporter activity
           |   |__L-glutamate:proton antiporter activity(+) 1 rec.
           |   |__L-glutamine, sodium:proton antiporter activity
           |   |__L-histidine, sodium:proton antiporter activity
           |__arginine:agmatine antiporter activity
           |__arginine:ornithine antiporter activity
           |__aspartate:alanine antiporter activity
           |__ATP:ADP antiporter activity 2 rec.
           |__azole:proton antiporter activity
           |   |__aminotriazole:proton antiporter activity
           |   |__fluconazole:proton antiporter activity
           |   |__L-histidine, sodium:proton antiporter activity
           |__benomyl:proton antiporter activity
           |__bicarbonate:monoatomic anion antiporter activity 1 rec.
           |   |__chloride:bicarbonate antiporter activity(+) 1 rec.
           |__broad specificity neutral L-amino acid:basic L-amino acid antiporter activity
           |__carnitine:O-acyl-L-carnitine antiporter activity
           |__citrate:2-oxoglutarate antiporter activity
           |__citrate:succinate antiporter activity
           |__cycloheximide:proton antiporter activity
           |__cystine:glutamate antiporter activity
           |__folate:monoatomic anion antiporter activity
           |__glutamate:gamma-aminobutyric acid antiporter activity
           |__GTP:GDP antiporter activity
           |__L-aspartate:fumarate antiporter activity
           |__L-histidine:histamine antiporter activity
           |__L-lysine:L-arginine antiporter activity
           |__lysine:cadaverine antiporter activity
           |__metal cation:monoatomic cation antiporter activity 23 rec.
           |   |__calcium:monoatomic cation antiporter activity(+) 15 rec.
           |   |__magnesium:sodium antiporter activity
           |   |__metal cation:proton antiporter activity(+) 10 rec.
           |   |__sodium,bicarbonate:chloride antiporter activity
           |   |__solute:potassium antiporter activity(+) 12 rec.
           |__monoamine:proton antiporter activity 3 rec.
           |__orotate:monoatomic anion antiporter activity
           |__oxoglutarate:malate antiporter activity
           |__polyamine:proton antiporter activity
           |__polyspecific organic cation:proton antiporter activity
           |__putrescine:ornithine antiporter activity
           |__S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
           |__solute:inorganic anion antiporter activity 10 rec.
           |   |__chloride:bicarbonate antiporter activity(+) 1 rec.
           |   |__chloride:proton antiporter activity 3 rec.
           |   |__dicarboxylate:phosphate antiporter activity
           |   |__organophosphate:phosphate antiporter activity(+) 3 rec.
           |   |__oxalate:chloride antiporter activity
           |   |__sulfate:bicarbonate antiporter activity
           |   |__sulfate:chloride antiporter activity
           |__succinate:fumarate antiporter activity
           |__tartrate:succinate antiporter activity
           |__tetracycline:proton antiporter activity
           |__tyrosine:tyramine antiporter activity
           |__urate:monoatomic anion antiporter activity
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Is a secondary active transmembrane transporter activity
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Synonyms
  • "antiport" RELATED
    "countertransporter activity" EXACT
    "exchange transporter activity" EXACT
    "exchanger" BROAD
    "ion antiporter activity" NARROW
    "porter" BROAD
    "solute:solute antiporter activity" EXACT
    "solute:solute exchange" RELATED
Secondary IDs
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Reactome:R-HSA-2730692 "CLCN4/5/6 exchange Cl- for H+"
Reactome:R-HSA-2730959 "CLCN7:OSTM1 exchanges Cl- for H+"
Reactome:R-HSA-2731002 "CLCN3 exchanges Cl- for H+"