FB2025_01 , released February 20, 2025
Allele: Dmel\ea2
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General Information
Symbol
Dmel\ea2
Species
D. melanogaster
Name
FlyBase ID
FBal0003456
Feature type
allele
Associated gene
Dmel\ea
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ray et al., 1991)

gain of function allele

(Ray et al., 1991)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Point mutation in the catalytic site.

(Lemaitre et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Bacterially challenged ea2/ea7 mutants exhibit a wild type Drs response. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate. Infection of ea1/ea2 mutants with A.fumigatus causes higher survival rate than wild type, infection with E.coli causes 87% survival 3 days postinfection.

      (Lemaitre et al., 1996)

      Perivitelline fluid from Tl and dl donors was capable of restoring polarized gastrulation movements and cuticular elements. Perivitelline fluid transplantation using eaD8 embryos as donors and ea1/ea2 embryos as recipients demonstrated that the rescue of the ea phenotype results from the transplantation of the ea gene product.

      (Stein and Nusslein-Volhard, 1992)

      Ventralized embryos: rings or patches of ventral denticles along dorsoventral axis. Altered pattern of dpp and zen.

      (Ray et al., 1991)

      Embryos derived from homozygous females are dorsalised.

      (Carroll et al., 1987)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      ea2 is a non-suppressor of partially lethal - majority die | recessive phenotype of cact7

      (Qiu et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos derived from Spn27Aex32/Df(2L)BSC7 ; ea1/ea2 females are completely dorsalised.

      (Ligoxygakis et al., 2003)

      The zygotic semi-lethality of cact7 homozygotes is not suppressed by ea2.

      (Qiu et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ea2
      (Alpar et al., 2018, Cho et al., 2010, Leclerc et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)