FlyBase Allele Report: Dmel\scny[02331]

General Information

Symbol

Dmel\scny⁰²³³¹

Species

D. melanogaster

Name

FlyBase ID

FBal0009444

Feature type

allele

Associated gene

Dmel\scny

Associated Insertion(s)

P{PZ}scny⁰²³³¹

Carried in Construct

Also Known As

l(3)02331

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

Progenitor genotype

Associated Insertion(s)

P{PZ}scny⁰²³³¹

Cytology

Description

Insertion in an intron.

(Ribaya et al., 2009)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:5,770,681..5,770,681 [+]

(Ribaya et al., 2009, Spradling et al., 1999, Harvie et al., 1998, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with scny^f01742)

(Buszczak et al., 2009)

female sterile (with scny^roo)

(Ribaya et al., 2009)

lethal (with Df(3L)ZN47)

(Buszczak et al., 2009)

lethal (with scny^e00340)

(Buszczak et al., 2009)

lethal | recessive

(Buszczak et al., 2009, Ribaya et al., 2009, Spradling et al., 1999, Harvie et al., 1998)

male sterile (with scny^roo)

(Ribaya et al., 2009)

partially lethal - majority die (with scny^f01742)

(Buszczak et al., 2009)

semi-fertile (with scny^d06513)

(Buszczak et al., 2009)

Phenotype Manifest In

female germline stem cell (with scny^d06513)

(Buszczak et al., 2009)

female germline stem cell | somatic clone

(Buszczak et al., 2009)

follicle stem cell | somatic clone

(Buszczak et al., 2009)

gonad (with scny^roo)

(Ribaya et al., 2009)

intestinal stem cell (with scny^f01742)

(Buszczak et al., 2009)

Detailed Description

Statement

Reference

Usp36⁰²³³¹ dominantly suppresses position effect variegation of eye color due to In(1)w^m4h/+.

The half life of follicle stem cells in Usp36⁰²³³¹ homozygous clones significantly reduced compared to wild-type. But mutant follicle cells develop normally.

In Usp36^f01742/Usp36⁰²³³¹ adults, intestinal stem cells are present at near normal numbers at eclosion but are rapidly lost so that few are left by 7 days post eclosion. This phenotype is partially suppressed by the addition of 8mM DAPT (a gamma-secretase inhibitor) to the food. Unlike wild-type adults, mutants treated with DAPT do not form tumors.

(Buszczak et al., 2009)

The number of female germline stem cells in the germaria of Usp36^d06513/Usp36⁰²³³¹ adult females is reduced compared to wild-type.

The half life of female germline stem cells in Usp36⁰²³³¹ somatic clones is sharply reduced compared to wild-type.

(Buszczak et al., 2009)

scny⁰²³³¹/scny^roo males and females are sterile, with tiny gonads.

(Ribaya et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

scny^GS13655

(Ribaya et al., 2009)

scny^EY08858

(Ribaya et al., 2009)

scny^e00340

(Ribaya et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

11565

P{PZ}scny⁰²³³¹ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

Notes on Origin

Discoverer

A. Spradling.

Comments

Complements: Bre1⁰¹⁶⁴⁰. Complements: l(3)05143⁰⁵¹⁴³. Complements: vn¹⁰⁵⁶⁷. Complements: vn^rF264.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Usp36⁰²³³¹

et^l(3)02331

(Ribaya et al., 2009)

l(3)02331

(Buszczak et al., 2009, Ribaya et al., 2009, Spradling et al., 1999)

l(3)02331⁰²³³¹

scny⁰²³³¹

(Ribot et al., 2022, Morillo Prado et al., 2013, Cook and Cook, 2010.5.7)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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