FlyBase Allele Report: Dmel\Arr1[1]

General Information

Symbol

Dmel\Arr1¹

Species

D. melanogaster

Name

FlyBase ID

FBal0042401

Feature type

allele

Associated gene

Dmel\Arr1

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Satoh and Ready, 2005, Ranganathan and Stevens, 1995)

loss of function allele

(Meyer et al., 2006)

Mutagen

ethyl methanesulfonate

(Dolph et al., 1993)

Progenitor genotype

Cytology

Description

5kb insertion of foreign DNA (probably a transposable element) in the second intron.

(Dolph et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

2L:18,079,724..18,079,956 [+]

Comment:

An insertion of ~5kb (probably a transposable element) into the second intron.

(Dolph et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal smell perception (with Df(2L)II30)

(Merrill et al., 2002)

abnormal smell perception | dominant

(Merrill et al., 2002)

increased cell death

(Satoh and Ready, 2005)

Phenotype Manifest In

eye photoreceptor cell

(Satoh and Ready, 2005)

ommatidial cluster & endocytic vesicle

(Satoh and Ready, 2005)

rhabdomere

(Satoh and Ready, 2005)

Detailed Description

Statement

Reference

Investigation of trpl^{ninaE.T:Avic\GFP-EGFP} translocation in Arr1¹ mutants reveals no significant difference from wild-type photoreceptors.

(Meyer et al., 2006)

Light-dependent ninaE endocytosis is blocked in Arr1¹ pupal photoreceptors. As with wild-type flies, 12L/12D-reared Arr1¹ mutants have intact photoreceptors at eclosion. At 3 days posteclosion, Arr1¹ photoreceptors show numerous multivesicular bodies and abnormal membrane tubules that extend from the rhabdomere base. By 6 days many photoreceptors are degenerate; some are engulfed by neighbouring cells and some are condensed and dark, while other degenerating photoreceptors have necrotic features, including large cytoplasmic vacuoles and cell swelling. Degeneration is slower in dark-reared Arr1¹ photoreceptors, but is overall similar to degeneration in 12D/12L.

(Satoh and Ready, 2005)

Arr1¹ heterozygotes show a decrease in electropalpogram amplitude in response to the odor of butanol, compared to a control strain. A similar phenotype is seen in Df(2L)II30/Arr1¹ flies.

(Merrill et al., 2002)

Whole cell voltage clamp recording of the light activated response of mutant photoreceptor cells show a wild type rate of deactivation (defined as the recovery of the photoresponse after termination of the stimulus).

(Dolph et al., 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Arr1¹ has increased cell death phenotype, suppressible by Arr2³

(Satoh and Ready, 2005)

Arr1¹ has increased cell death phenotype, suppressible by Arr2⁵

(Satoh and Ready, 2005)

Arr1¹ has increased cell death phenotype, suppressible by Scer\GAL4^ninaE.PHS/BacA\p35^UAS.cHa

(Satoh and Ready, 2005)

Phenotype Manifest In

Suppressed by

Statement

Reference

Arr1¹ has eye photoreceptor cell phenotype, suppressible by Scer\GAL4^ninaE.PHS/BacA\p35^UAS.cHa

(Satoh and Ready, 2005)

Arr1¹ has eye photoreceptor cell phenotype, suppressible by Arr2³

(Satoh and Ready, 2005)

Arr1¹ has eye photoreceptor cell phenotype, suppressible by Arr2⁵

(Satoh and Ready, 2005)

Arr1¹ has ommatidial cluster & endocytic vesicle phenotype, suppressible by Arr2⁵

(Satoh and Ready, 2005)

Arr1¹ has rhabdomere phenotype, suppressible by Arr2³

(Satoh and Ready, 2005)

Arr1¹ has rhabdomere phenotype, suppressible by Arr2⁵

(Satoh and Ready, 2005)

Enhancer of

Statement

Reference

Arr1¹ is an enhancer of eye photoreceptor cell phenotype of Arr2³

(Meyer et al., 2006)

Arr1¹ is an enhancer of phenotype of Arr2³

(Dolph et al., 1993)

Suppressor of

Statement

Reference

Arr1¹ is a suppressor of photoreceptor neuron | adult stage phenotype of Culd^e01982

(Xu and Wang, 2016)

Other

Statement

Reference

Arr1¹, Arr2³ has eye photoreceptor cell phenotype

(Meyer et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

The vesicular accumulations of ninaE and trpl proteins in the cytosol of photoreceptor cells in adult retina upon light exposure characteristic for Culd^e01982 mutants are fully rescued by combination with Arr1¹.

(Xu and Wang, 2016)

trpl^{ninaE.T:Avic\GFP-EGFP} translocation is severely inhibited in Arr1¹; Arr2³ double mutant photoreceptors. trpl^{ninaE.T:Avic\GFP-EGFP} is observed in the rhabdomeres of bouth light- and dark-raised flies.

(Meyer et al., 2006)

When Arr1¹ mutants are also mutant for Arr2⁵, photoreceptor degeneration is suppressed in adults and ninaE endocytosis is restored in pupae. Likewise, Arr1¹;Arr2³ flies show no photoreceptor degeneration.

(Satoh and Ready, 2005)

Arr1¹; Arr2³ double mutants exhibit a decrease in rate of deactivation that is more severe than Arr2³ homozygotes.

(Dolph et al., 1993)

Xenogenetic Interactions

Statement

Reference

Expression of BacA\p35^Scer\UAS.cHa, under the control of Scer\GAL4^ninaE.PHS, partially rescues Arr1¹ mutant photoreceptor degeneration.

(Satoh and Ready, 2005)

Complementation and Rescue Data

Rescued by

Arr1¹ is rescued by Scer\GAL4^ninaE.PHS/Arr1^UAS.cZa

(Satoh and Ready, 2005)

Not rescued by

Arr1¹ is not rescued by Arr1^ninaE.EGFP

(Shieh et al., 2014)

Comments

The decrease in electropalpogram amplitude in response to the odor of butanol seen in Arr1¹/+ flies partially rescued by the presence of Dp(2;Y)H3.

(Merrill et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42252

Arr1¹ cn¹ bw¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Arr1¹

(Shieh et al., 2014)

arr1¹

(Ferng et al., 2024, Yamashita et al., 2022, Mu et al., 2019, Xu and Wang, 2016, Rosenbaum et al., 2011, Mecklenburg et al., 2010, Meyer et al., 2006, Rosenbaum et al., 2006, Merrill et al., 2005, Satoh and Ready, 2005, Ranganathan and Stevens, 1995)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

Open Close