FB2025_01 , released February 20, 2025
Allele: Dmel\sevV1
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General Information
Symbol
Dmel\sevV1
Species
D. melanogaster
Name
FlyBase ID
FBal0051156
Feature type
allele
Associated gene
Dmel\sev
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mullins and Rubin, 1991)
Progenitor genotype
Cytology
Description

Amino acid replacement: G2221D. G2221 is in the ATP-binding site of the tyrosine kinase domain.

(Mullins and Rubin, 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:11,072,936..11,072,936 [-]
Nucleotide change:

G11072936A

Amino acid change:

G2216D | sev-PA

Reported amino acid change:

G2221D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Mullins and Rubin, 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sevV1 lack most R7 photoreceptor cells when raised at the non-permissive temperature of 29[o]C.

      (Ting et al., 2007)

      Homozygous flies have wild-type ommatidia at 18oC, but only 4% of ommatidia have R7 cell rhabdomeres at 28oC.

      (Mullins and Rubin, 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Removing neighboring R7 photoreceptor cells through a sevV1 background greatly increases the tendency of Kap-α3D93 mutant R7s to invade adjacent targets. Approximately 84.3% of isolated Kap-α3D93 R7 terminals extend laterally into neighboring columns (as compared to 23% for Kap-α3D93 mutants in a wild-type background), with 22% of these lateral extensions spanning several columns.

      Removing neighboring R7 photoreceptor cells through a sevV1 background greatly increases the tendency of babo9 mutant R7s to invade adjacent targets. Approximately 75% of isolated babo9 R7 terminals extend laterally into neighboring columns (as compared to 12.7% for babo9 mutants in a wild-type background).

      Removing neighboring R7 photoreceptor cells through a sevV1 background greatly increases the tendency of babo9 mutant R7s to invade adjacent targets. Approximately 75% of isolated babo9 R7 terminals extend laterally into neighboring columns (as compared to 12.7% for babo9 mutants in a wild-type background).

      Removing neighboring R7 photoreceptor cells through a sevV1 background greatly increases the tendency of Kap-α3D93 mutant R7s to invade adjacent targets. Approximately 84.3% of isolated Kap-α3D93 R7 terminals extend laterally into neighboring columns (as compared to 23% for Kap-α3D93 mutants in a wild-type background), with 22% of these lateral extensions spanning several columns.

      Although modest, the tiling phenotype found in ActβdsRNA.HL.Scer\UAS mutants is considerably enhanced when neighboring R7s are removed.

      Although modest, the tiling phenotype found in ActβCM.Scer\UAS mutants is considerably enhanced when neighboring R7s are removed. Approximately 36% of mutant R7s extend laterally into unoccupied columns.

      When neighboring wild-type R7 axons are removed through the presence of sevV1, GlΔ.Scer\UAS mutant R7 axons extend into adjacent columns.

      (Ting et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      sevV1
      (Holbrook et al., 2012, Ting et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)