Allele Dmel\nau^Scer\UAS.cKa

General Information
Symbol	Dmel\nau^Scer\UAS.cKa	Species	D. melanogaster
Name		FlyBase ID	FBal0056459
Feature type	allele	Associated gene	Dmel\nau

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Keller et al., 1997, Keller et al., 1998)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: 1.4kb nau fragment extending from nucleotide +300 (98 nucleotides 5' to the nau translation start site) to the end of the cDNA is cloned into the pUAST vector. (Keller et al., 1997)
Carried in construct	P{UAS-nau.K} (Balagopalan et al., 2001, Keller et al., 1998, Keller et al., 1997, Dubois et al., 2007, Enriquez et al., 2010)
Cytology
Phenotypic Data
Phenotypic Class
	flightless, with Scer\GAL4^how-24B (Keller et al., 1997) lethal, with Scer\GAL4^how-24B (Keller et al., 1997)
Phenotype Manifest In
	cardioblast, with Scer\GAL4^how-24B (Keller et al., 1997) myoblast, with Scer\GAL4^how-24B (Keller et al., 1997) somatic mesoderm, with Scer\GAL4^how-24B (Keller et al., 1997)
Detailed Description
	Statement Reference Scer\GAL4^how-24B mediated expression causes some lethality during embryonic, larval and pupal development. A limited number survive to adulthood and have severe defects in their ability to fly. Scer\GAL4^how-24B mediated expression causes myoblast fusion and elongation. Cardial cells are transformed into somatic muscle and the pattern of somatic muscle fibres is changed. (Keller et al., 1997)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Other
Statement Reference Scer\GAL4^how-24B/Scer\GAL4^how-24B, kn^Scer\UAS.cVa, nau^Scer\UAS.cKa has dorsal acute muscle \| ectopic phenotype (Enriquez et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of kn[Scer\UAS.cVa] and nau[Scer\UAS.cKa] using Scer\GAL4[how-24B] results in an ectopic DA3 muscle in thoracic segment 1 with very few nuclei (2-3). (Enriquez et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^how-24B, Scer\GAL4^how-24B, nau^Scer\UAS.cKa rescues Df(3R)nau-9/Df(3R)nau-11a4 (Keller et al., 1998)
Partially rescues	Scer\GAL4^how-24B, Scer\GAL4^how-24B, nau^Scer\UAS.cKa partially rescues Df(3R)nau-9/Df(3R)nau-11a4 (Balagopalan et al., 2001)
Comments	Expression of nau^Scer\UAS.cKa under the control of Scer\GAL4^how-24B rescues the sterility of Df(3R)nau-11a4/Df(3R)nau-9 females. Rescue of the nau mutant phenotype is not complete; survival rates of the progeny of these females are 50% in larvae, 47% in pupae and 44% in adults. (Balagopalan et al., 2001) Df(3R)nau-11a4/Df(3R)nau-9 embryos lack subset of muscle fibres, including the dorsal oblique, dorsal acute and lateral longitudinal muscles. Df(3R)nau-11a4/Df(3R)nau-9 embryos expressing nau^Scer\UAS.cKa under the control of Scer\GAL4^how-24B do not show significant absence of these muscle fibres. (Keller et al., 1998)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	nau^Scer\UAS.cKa nau^UAS.cKa
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Enriquez et al., 2010, Development 137(3): 457--466 Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo. [FBrf0209729] Dubois et al., 2007, Development 134(24): 4347--4355 collier transcription in a single Drosophila muscle lineage: the combinatorial control of muscle identity. [FBrf0200492] Balagopalan et al., 2001, Dev. Biol. 231(2): 374--382 Loss-of-function mutations reveal that the Drosophila nautilus gene is not essential for embryonic myogenesis or viability. [FBrf0134546] Keller et al., 1998, Dev. Biol. 202(2): 157--171 A role for nautilus in the differentiation of muscle precursors. [FBrf0105257] Keller et al., 1997, Dev. Biol. 181(2): 197--212 Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers. [FBrf0091320]

Allele Dmel\nauScer\UAS.cKa

Allele Dmel\nau^Scer\UAS.cKa