FB2025_01 , released February 20, 2025
Allele: Dmel\nauUAS.cKa
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General Information
Symbol
Dmel\nauUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0056459
Feature type
allele
Associated gene
Dmel\nau
Associated Insertion(s)
Carried in Construct
P{UAS-nau.K}
Also Known As
UAS-nau
Key Links
Transgenic product class
cDNA
(Keller et al., 1997)
wild_type
(Keller et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Keller et al., 1997)
wild_type
(Keller et al., 1997)
Mutagen
in vitro construct
(Keller et al., 1998, Keller et al., 1997)
Progenitor genotype
Carried in construct
P{UAS-nau.K}
Cytology
Description

UASt regulatory sequences drive expression of a 1.4kb nau cDNA fragment extending from 98 nucleotides 5' to the nau translation start site to the end of the cDNA.

(Keller et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
nau
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Scer\GAL4how-24B mediated expression causes some lethality during embryonic, larval and pupal development. A limited number survive to adulthood and have severe defects in their ability to fly. Scer\GAL4how-24B mediated expression causes myoblast fusion and elongation. Cardial cells are transformed into somatic muscle and the pattern of somatic muscle fibres is changed.

      (Keller et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of knScer\UAS.cVa and nauScer\UAS.cKa using Scer\GAL4how-24B results in an ectopic DA3 muscle in thoracic segment 1 with very few nuclei (2-3).

      (Enriquez et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4how-24B/nauUAS.cKa rescues Df(3R)nau-9/Df(3R)nau-11a4

      (Keller et al., 1998)
      Partially rescues

      Scer\GAL4how-24B/nauUAS.cKa partially rescues Df(3R)nau-9/Df(3R)nau-11a4

      (Balagopalan et al., 2001)
      Comments

      Expression of nauScer\UAS.cKa under the control of Scer\GAL4how-24B rescues the sterility of Df(3R)nau-11a4/Df(3R)nau-9 females. Rescue of the nau mutant phenotype is not complete; survival rates of the progeny of these females are 50% in larvae, 47% in pupae and 44% in adults.

      (Balagopalan et al., 2001)

      Df(3R)nau-11a4/Df(3R)nau-9 embryos lack subset of muscle fibres, including the dorsal oblique, dorsal acute and lateral longitudinal muscles. Df(3R)nau-11a4/Df(3R)nau-9 embryos expressing nauScer\UAS.cKa under the control of Scer\GAL4how-24B do not show significant absence of these muscle fibres.

      (Keller et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      nauScer\UAS.cKa
      nauUAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (6)