FB2025_01 , released February 20, 2025
Allele: Dmel\l(2)k10317k10317
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General Information
Symbol
Dmel\l(2)k10317k10317
Species
D. melanogaster
Name
FlyBase ID
FBal0064210
Feature type
allele
Associated gene
l(2)k10317
Associated Insertion(s)
P{lacW}MESK2k10317
Carried in Construct
Also Known As
l(2)k10317
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}MESK2k10317
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      l(2)k10317k10317/l(2)k10317[+] is a suppressor of visible phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2008)

      l(2)k10317k10317/l(2)k10317[+] is a suppressor of visible phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

      (Kucherenko et al., 2008)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      l(2)k10317k10317/l(2)k10317[+] is a suppressor of posterior crossvein phenotype of DysRNAi.NH2.UAS, Scer\GAL4Act.PU

      (Kucherenko et al., 2008)

      l(2)k10317k10317/l(2)k10317[+] is a suppressor of posterior crossvein phenotype of DysRNAi.C.UAS, Scer\GAL4Tub.PU

      (Kucherenko et al., 2008)
      Other
      Statement
      Reference

      DysRNAi.NH2.UAS, l(2)k10317k10317/l(2)k10317[+] has wing vein | ectopic phenotype

      (Kucherenko et al., 2008)

      DysRNAi.C.UAS, l(2)k10317k10317/l(2)k10317[+] has wing vein | ectopic phenotype

      (Kucherenko et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of l(2)k10317k10317 strongly suppresses the detached posterior crossvein phenotype seen when DysdsRNA.NH2.Scer\UAS is expressed under the control of Scer\GAL4Act.PU but produces extra wing vein material.

      One copy of l(2)k10317k10317 moderately suppresses the detached posterior crossvein phenotype seen when DysdsRNA.C.Scer\UAS is expressed under the control of Scer\GAL4tub.PU but produces extra wing vein material.

      (Kucherenko et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)

      Deficiency complementation analysis is consistent with the lethality of the line being associated with the insertion. The insertion maps within the MESK2 transcription unit. However, since the insertion lies within a gene-rich region, the lethality can not yet be conclusively mapped to a single gene from these results. Thus l(2)k10317k10317 (representing the lethality of the chromosome) has been kept as a separate allele in FlyBase for now.

      (Kahsai et al., 2016)
      Comments
      Comments

      Complements: Fkbp1300734. Complements: MESK201467. Complements: Egfr05351. Complements: MESK208882. Complements: Sdc10608.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      l(2)k10317
      (Kucherenko et al., 2008, Spradling et al., 1999)
      l(2)k10317k10317
      Name Synonyms
      Secondary FlyBase IDs
        References (4)