FB2025_01 , released February 20, 2025
Allele: Dmel\domeG0405
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General Information
Symbol
Dmel\domeG0405
Species
D. melanogaster
Name
FlyBase ID
FBal0100280
Feature type
allele
Associated gene
Dmel\dome
Associated Insertion(s)
P{lacW}domeG0405
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Castelli-Gair Hombria, 2001.9.19)
Mutagen
P-element activity
(Schäfer et al., 1999.8.12)
Progenitor genotype
Associated Insertion(s)
P{lacW}domeG0405
Cytology
Description

P{lacW} insertion in the 5' untranslated region.

(Chen et al., 2002)

P{lacW} insertion in the 5' UTR, at nucleotide position 20 of dome EST LD32858.

(Brown et al., 2001)

Insertion of P{lacW} intp 5' UTR of dome, at position of 20bp with respect to the start of LD32858.

(Castelli-Gair Hombria, 2001.9.19)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ427014
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have wild-type posterior spiracles.

      (Chen et al., 2002)

      Lethality occurs during the first and second larval instars.

      (Peter et al., 2002)

      The shape of the posterior spiracles is affected in mutants.

      (Brown et al., 2001)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.8.12)

      Mobilisation of the P-element reverts both the lethality and posterior spiracle phenotype.

      (Brown et al., 2001)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      dome405
      (Brown et al., 2001, Castelli-Gair Hombria, 2001.9.19)
      domeG0405
      l(1)G0405
      (Chen et al., 2002, Peter et al., 2002)
      l(1)G0405G0405
      (Schäfer et al., 1999.8.12)
      mom4
      (Chen et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)