FB2025_01 , released February 20, 2025
Allele: Dmel\GluClαglc1
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General Information
Symbol
Dmel\GluClαglc1
Species
D. melanogaster
Name
FlyBase ID
FBal0120816
Feature type
allele
Associated gene
Dmel\GluClα
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: P298S.

    (Kane, 2000.8.18)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:19,764,305..19,764,305 [+]
    Nucleotide change:

    C19764305T

    Amino acid change:

    P221S | GluClalpha-PE; P299S | GluClalpha-PF; P299S | GluClalpha-PH; P299S | GluClalpha-PI; P300S | GluClalpha-PJ; P299S | GluClalpha-PK; P300S | GluClalpha-PL; P299S | GluClalpha-PM; P299S | GluClalpha-PN; P299S | GluClalpha-PO; P299S | GluClalpha-PP

    Reported amino acid change:

    P298S

    Comment:

    The reference strain has a Pro at residue 298 (TCG). This change is associated with drug resistance and reduced mobility relative to a strain with a Ser residue at this location.

    (Kane, 2000.8.18, Kane et al., 2000)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Kohlschutter-Tonz syndrome
        CEA with Indy302
        (Jeong et al., 2021)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        NOT Suppressor of
        Statement
        Reference

        GluClαglc1/GluClalpha[+] is a non-suppressor of abnormal neurophysiology | larval stage phenotype of Eaat1hypo

        (Peng et al., 2019)

        GluClαglc1/GluClalpha[+] is a non-suppressor of abnormal locomotor behavior | larval stage phenotype of Eaat1hypo

        (Peng et al., 2019)
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 1 )
        Crossreferences
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        GluClαglc1
        (Jeong et al., 2021)
        GluClαglc
        (Li et al., 2021)
        glc1
        (Kane et al., 2000)
        gluClαglc1
        (Peng et al., 2019)
        Name Synonyms
        Secondary FlyBase IDs
          References (5)