Allele Dmel\fru^P14

General Information
Symbol	Dmel\fru^P14	Species	D. melanogaster
Name		FlyBase ID	FBal0126395
Feature type	allele	Associated gene	Dmel\fru

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Deficiency breakpoint in fru. Deletion extends proximally, deleting all fru coding sequences. (Anand et al., 2001)
Caused by aberration	Df(3R)P14 (Lee et al., 2000, Anand et al., 2001, Song et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| male (with fru^4-40) (Anand et al., 2001) lethal \| prepupal stage (with fru^AJ96u3) (Song et al., 2002) neuroanatomy defective (with Df(3R)fru^w24) (Song et al., 2002) neuroanatomy defective (with fru^AJ96u3) (Song et al., 2002) neuroanatomy defective (with fru^w12) (Song et al., 2002) viable (with fru^4-40) (Lee et al., 2000, Anand et al., 2001) viable (with fru^M5) (Lee et al., 2000, Anand et al., 2001)
Phenotype Manifest In
	aCC neuron (with fru^w12) (Song et al., 2002) joint (with fru^w12) (Anand et al., 2001) longitudinal connective (with Df(3R)fru^w24) (Song et al., 2002) longitudinal connective (with fru^AJ96u3) (Song et al., 2002) longitudinal connective (with fru^w12) (Song et al., 2002) macrochaeta \| ectopic (with fru^w12) (Anand et al., 2001) presumptive embryonic/larval central nervous system (with fru^AJ96u3) (Song et al., 2002) wing (with fru^w12) (Anand et al., 2001)
Detailed Description
	Statement Reference 20.5% of fru^w12/fru^P14 embryos have abnormal Fas2-positive fascicles in the central nervous system. The developing medial Fas2-positive fascicle is indistinct in stage 13 embryos and the aCC neuron sometimes either joins the ascending pCC axon or grows posteriorly (instead of extending peripherally as occurs in wild-type embryos). 25.5% of fru^P14/Df(3R)fru^w24 embryos have abnormal Fas2-positive fascicles in the central nervous system. 24.5% of fru^AJ96u3/fru^P14 embryos have abnormal Fas2-positive fascicles and 17.0% have defects in the distribution and pattern of BP102-positive axons in the central nervous system. fru^P14/fru^4-40 embryos have normal Fas2-positive and BP102-positive axon tracts in the central nervous system. (Song et al., 2002) Male-female courtship as measured by courtship index (CI) or wing extension index (WEI) is almost completely abolished in fru^P14/fru^4-40 males. fru^w12/fru^P14 adults that have been dissected from the pupal case show minor external defects, such as uninflated wings, wings held at a 70-90^o angle to the body, leg joint defects and duplicated bristles. (Anand et al., 2001)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	fru^P14 P14 (Song et al., 2002)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Arbeitman et al., 2004, Development 131(9): 2007--2021 A genomic analysis of Drosophila somatic sexual differentiation and its regulation. [FBrf0174573] Song et al., 2002, Genetics 162(4): 1703--1724 The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. [FBrf0155804] Anand et al., 2001, Genetics 158(4): 1569--1595 Molecular genetic dissection of the sex-specific and vital functions of the Drosophila melanogaster sex determination gene fruitless. [FBrf0138404] Lee et al., 2000, J. Neurobiol. 43(4): 404--426 Spatial, temporal, and sexually dimorphic expression patterns of the fruitless gene in the Drosophila central nervous system. [FBrf0128543]

Allele Dmel\fruP14

Allele Dmel\fru^P14