Reference Report

Reference
Citation	Song, H.J., Billeter, J.C., Reynaud, E., Carlo, T., Spana, E.P., Perrimon, N., Goodwin, S.F., Baker, B.S., Taylor, B.J. (2002). The fruitless gene is required for the proper formation of axonal tracts in the embryonic central nervous system of Drosophila. Genetics 162(4): 1703--1724. (Export to RIS)
FlyBase ID	FBrf0155804
Publication Type	Research paper
PubMed ID	12524343
PubMed Abstract	The fruitless (fru) gene in Drosophila melanogaster is a multifunctional gene that has sex-specific functions in the regulation of male sexual behavior and sex-nonspecific functions affecting adult viability and external morphology. While much attention has focused on fru's sex-specific roles, less is known about its sex-nonspecific functions. We have examined fru's sex-nonspecific role in embryonic neural development. fru transcripts from sex-nonspecific promoters are expressed beginning at the earliest stages of neurogenesis, and Fru proteins are present in both neurons and glia. In embryos that lack most or all fru function, FasII- and BP102-positive axons have defasciculation defects and grow along abnormal pathways in the CNS. These defects in axonal projections in fru mutants were rescued by the expression of specific UAS-fru transgenes under the control of a pan-neuronal scabrous-GAL4 driver. Our results suggest that one of fru's sex-nonspecific roles is to regulate the pathfinding ability of axons in the embryonic CNS.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (7)
	Df(3L)XDI98 Df(3R)Cha^M5 Df(3R)fru^4-40 Df(3R)fru^AJ96u3 Df(3R)fru^sat15 Df(3R)fru^w24 Df(3R)P14
Alleles (27)
	Ecol\lacZ^AA142 Ecol\lacZ^AJ96 Ecol\lacZ^fru-3 Ecol\lacZ^fru-4 Ecol\lacZ^fru-sat fru^0-1 fru¹ fru³ fru^4-40 fru⁴ fru^{A.Scer\UAS.cSa} fru^AJ96u3 fru^{B.Scer\UAS.cSa} fru^{C.Scer\UAS.cSa} fru^M5 fru^{MA.Scer\UAS.cSa} fru^{MB.Scer\UAS.cSa} fru^{MC.Scer\UAS.cSa} fru^P14 fru^sat15 fru^sat fru^w12 fru^w27 Scer\GAL4^elav-C155 Scer\GAL4^sca-537.4 sprd⁰⁵²⁸⁴ w^+mC
Constructs (6)
	P{UAS-fru.A.S} P{UAS-fru.B.S} P{UAS-fru.C.S} P{UAS-fru.MA.S} P{UAS-fru.MB.S} P{UAS-fru.MC.S}
Genes (12)
	Ecol\lacZ elav en Fas2 fru futsch hb odd repo Scer\GAL4 sprd w
Insertions (7)
	P{GawB}elav^C155 P{GawB}sca^537.4 P{lacZ}AJ96 P{lwB}AA142 P{lwB}fru^sat P{PZ}fru³ P{PZ}fru⁴