FB2025_01 , released February 20, 2025
Allele: Dmel\beat-IcRM5
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General Information
Symbol
Dmel\beat-IcRM5
Species
D. melanogaster
Name
FlyBase ID
FBal0130496
Feature type
allele
Associated gene
Dmel\beat-Ic
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Caused by aberration
    Df(2L)RM5
    Cytology
    Description

    Aberration breakpoint in beat-Ic.

    (Pipes et al., 2001)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        19% of beat-IcRM5/Df(2L)TE35D-19 embryos show abnormalities in development of the ISNb nerve. The embryos show defects in fasciculation of the transverse nerve; at late stage 16, the transverse motor nerve (TMN) and lateral bipolar dendrite (LBD) neurons are bifurcated and exploring the surface of the ventral muscles in 20% of cases (these neurons are tightly fasciculated to form the transverse nerve at the same stage in wild-type embryos).

        (Pipes et al., 2001)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        beat-Ic[+]/beat-IcRM5 is a suppressor | partially of larval intersegmental nerve phenotype of Df(2L)RM5/beat-Ia466

        (Pipes et al., 2001)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        46% of ISNb nerves show a bypass phenotype in beat-Ia466/Df(2L)RM5 embryos (Df(2L)RM5 deletes beat-Ia and disrupts beat-Ic, causing the beat-IcRM5 allele), 4% of ISNb nerves are wild type. 83% of ISNd nerves show a bypass phenotype in beat-Ia466/Df(2L)RM5 embryos (17% of ISNd nerves are wild type).

        (Pipes et al., 2001)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        Df(2L)TE35D-19/beat-IcRM5 is partially rescued by beat-IcUAS.cPa/Scer\GAL4elav.PLu

        (Pipes et al., 2001)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        beat-IcRM5
        Name Synonyms
        Secondary FlyBase IDs
          References (1)