FlyBase Allele Report: Dmel\akirin[EP906]

General Information

Symbol

Dmel\akirin^EP906

Species

D. melanogaster

Name

FlyBase ID

FBal0131363

Feature type

allele

Associated gene

Dmel\akirin

Associated Insertion(s)

P{EP}akirin^EP906

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EP}akirin^EP906

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:7,369,919..7,369,919 [+]

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage

(Nowak et al., 2012)

some die during embryonic stage

(Nowak et al., 2012)

Phenotype Manifest In

larval somatic muscle cell (with akirin⁵)

(Nowak et al., 2012)

larval somatic muscle cell (with akirin^KG01343)

(Nowak et al., 2012)

Detailed Description

Statement

Reference

Homozygous embryos die shortly after stage 16 and do not hatch.

Homozygous germline clones have not been recovered.

akirin^KG01343/akirin^EP906 embryos show defects in the somatic musculature. 71.4% of embryos have missing muscles, 68.5% have muscle attachment defects and 25.7% have duplicated muscles. 67% of embryos have muscle defects in at least 2 hemisegments.

akirin⁵/akirin^EP906 embryos show defects in the somatic musculature. 35% of embryos have missing muscles, 35% have muscle attachment defects and 6% have duplicated muscles. 44.7% of embryos have muscle defects in at least 2 hemisegments.

(Nowak et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

akirin^EP906/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Phenotype Manifest In

Enhancer of

Statement

Reference

akirin^EP906/Scer\GAL4^pnr-MD237 is an enhancer of chaeta phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Other

Statement

Reference

akirin^EP906, twi¹/twi[+] has larval somatic muscle cell phenotype

(Nowak et al., 2012)

Bap60[+]/Bap60¹, akirin^EP906 has larval somatic muscle cell phenotype

(Nowak et al., 2012)

Scer\GAL4^pnr-MD237, akirin^EP906, pnr^MD237 has scutellar bristle | increased number phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, akirin^EP906, pnr^MD237/pnr[+] has scutellar bristle | increased number phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

akirin^EP906/+ results in disruption of the somatic muscle pattern when in double heterozygous combination with one of the following (% of stage 16 embryos with missing, misattached or duplicated muscles in at least 2 hemisegments is given in parentheses): twi¹ (18.1%) or Bap60¹ (20.2%).

(Nowak et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Separable from: a second unidentified lethal mutation on the chromosome.

(Nowak et al., 2012)

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG8580^EP906

akirin³

(Nowak et al., 2012)

akirin^EP(3)0906

(Nowak et al., 2012)

akirin^EP906

bhr^EP906

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

Open Close