FB2025_01 , released February 20, 2025
Allele: Dmel\sll7E18
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General Information
Symbol
Dmel\sll7E18
Species
D. melanogaster
Name
FlyBase ID
FBal0150252
Feature type
allele
Associated gene
Dmel\sll
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C127T.

    (Luders et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Females carrying homozygous follicle cell clones produce embryos with a dorsalised cuticle.

        (Zhu et al., 2007)

        The salivary glands are present in sll7E18 embryos.

        (Zhu et al., 2005)

        Homozygous animals do not hatch and produce cuticles with occasional fusions of denticle belts. Animals carrying sll7E18 clones in the wing frequently display a reduction in the region between longitudinal veins L3 and L4. Ectopic wing vein tissue is also seen associated with wing vein L2. This ectopic wing vein phenotype is also seen in sll7E18/sllS142214 clones. When sll7E18 clones are made in the follicle cells, the resulting eggs frequently exhibit dorsalisation of varying severity, ranging from partial and spatially restricted, to a complete loss of ventral structural elements.

        (Luders et al., 2003)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        When wgScer\UAS.cKa or hhScer\UAS.cIa is driven by Scer\GAL4prd.RG1 in sll7E18 animals suppression of the segment polarity phenotype is seen in those domains that express Scer\GAL4prd.RG1. The addition of sll7E18 to dallygem/dallyΔP-527 animals enhances the posterior postalar bristle phenotype - 30% of individuals show this phenotype.

        (Luders et al., 2003)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        sll7E18 is rescued by sllUAS.cLa/Scer\GAL4Act5C.PI

        (Luders et al., 2003)
        Partially rescued by

        sll7E18 is partially rescued by sllUAS.cLa/Scer\GAL4prd.RG1

        (Luders et al., 2003)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        sll7E18
        (Zhu et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)