FB2025_01 , released February 20, 2025
Allele: Dmel\ninaEStoA
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General Information
Symbol
Dmel\ninaEStoA
Species
D. melanogaster
Name
FlyBase ID
FBal0192082
Feature type
allele
Associated gene
Dmel\ninaE
Associated Insertion(s)
Carried in Construct
P{Rh1StoA}
Also Known As
Rh1CT S>A
Key Links
Transgenic product class
missense_variant
(Kiselev et al., 2000)
polypeptide_post_translational_processing_variant
(Kiselev et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Kiselev et al., 2000)
polypeptide_post_translational_processing_variant
(Kiselev et al., 2000)
Mutagen
in vitro construct
(Kiselev et al., 2000)
Progenitor genotype
Carried in construct
P{Rh1StoA}
Cytology
Description

Amino acid replacement: S357A. Amino acid replacement: S362A. Amino acid replacement: S367A. Amino acid replacement: S371A. Amino acid replacement: T365A. Amino acid replacement: S358V.

(Satoh and Ready, 2005)

Amino acid replacement: S?A. Contains S to A point mutations at all phosphorylation sites.

(Kiselev et al., 2000)
Allele components
Component
Use(s)
Encoded product / tool
ninaE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  retinal disease
      modeled by norpAP24
      (Kristaponyte et al., 2012)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Light-induced translocation of Arr1 and ninaE endocytosis in pupal eyes is reduced in ninaEStoA mutants.

      (Satoh and Ready, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ninaEStoA/ninaEΔ356 is a suppressor of abnormal neuroanatomy phenotype of norpAP24

      (Kristaponyte et al., 2012)

      ninaEStoA is a suppressor of abnormal neuroanatomy phenotype of norpAP24

      (Kristaponyte et al., 2012)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ninaE17/ninaEStoA is a suppressor of photoreceptor neuron phenotype of norpAP24

      (Kristaponyte et al., 2012)

      ninaE17/ninaEStoA is a suppressor of rhabdomere phenotype of norpAP24

      (Kristaponyte et al., 2012)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Twenty-day old norpA36 flies expressing ninaEStoA exhibit the full complement of R1-R6 rhabdomeres and display no sign of retinal degeneration. Rhabdomere degeneration is delayed in norpA36 flies expressing one copy of ninaEStoA in a ninaE17 mutant background, as rhabdomeres retain wild-type morphology for at least 3 weeks post-eclosion. At 4 weeks, some ommatidia exhibit signs of deterioration as characterised by missing and/or reduced rhabdomeres in norpA36 flies co-expressing ninaEStoA (in a ninaE17 background), but degeneration is greatly delayed compared to norpA36 flies.

      (Kristaponyte et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Rh1CTSA
      (Liu et al., 2008)
      Rh1CT S>A
      (Kristaponyte et al., 2012)
      ninaEStoA
      (Shieh et al., 2014)
      rh1<up>CT S>A</up>
      (Voolstra et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)