FB2025_01 , released February 20, 2025
Allele: Dmel\AmtEY21789
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General Information
Symbol
Dmel\AmtEY21789
Species
D. melanogaster
Name
FlyBase ID
FBal0192654
Feature type
allele
Associated gene
Dmel\Amt
Associated Insertion(s)
P{EPgy2}AmtEY21789
Carried in Construct
Also Known As
Amt1
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Menuz et al., 2014)
Mutagen
P-element activity
(Bellen, 2006.8.3)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}AmtEY21789
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The ac1 sensilla of homozygous flies shows a dramatically reduced electrophysiological response to ammonia over a range of concentrations (0.01% to 10%) compared to wild type. The mutant ac1 sensilla also shows reduced spontaneous activity levels.

      The response of the ac1 sensilla of homozygous flies to pyrrolidine, 2-oxovaleric acid, propanal or phenethylamine is normal.

      The response of the ac2 and ac3 sensilla of homozygous flies to ammonia, propanal, 1,4-diaminobutane or 1-hexanol is normal.

      The response of the ac4 sensilla of homozygous flies to ammonia, phenethylamine, pyrrolidine or propanal is normal.

      AmtEY21789/Df(3R)BSC471 flies also show a defective electrophysiological response to ammonia.

      (Menuz et al., 2014)

      Mutant flies show mild but significant defects in the auditory response to sound compared to wild type.

      (Senthilan et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Agam\AmtScer\UAS.cMa under the control of Scer\GAL4Amt.PM rescues the reduced response of AmtEY21789 flies to ammonia.

      (Menuz et al., 2014)
      Complementation and Rescue Data
      Rescued by

      AmtEY21789 is rescued by Amt+t14

      (Menuz et al., 2014)

      AmtEY21789 is rescued by Scer\GAL4Amt.PM/AmtUAS.cMa

      (Menuz et al., 2014)
      Comments

      Amt+t14 rescues the reduced response of AmtEY21789 flies to ammonia.

      Expression of AmtScer\UAS.cMa under the control of Scer\GAL4Amt.PM rescues the reduced response of AmtEY21789 flies to ammonia.

      (Menuz et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: a nearby lethal mutation on the chromosome.

      (Menuz et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Amt1
      (Vulpe et al., 2021, Delventhal et al., 2017, Menuz et al., 2014)
      AmtEY21789
      CG6499EY21789
      (Senthilan et al., 2012, Bellen, 2006.8.3)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)