FB2025_01 , released February 20, 2025
Allele: Dmel\laza1
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General Information
Symbol
Dmel\laza1
Species
D. melanogaster
Name
FlyBase ID
FBal0196200
Feature type
allele
Associated gene
Dmel\laza
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Kwon and Montell, 2006)
Progenitor genotype
lazaEY04417
(Kwon and Montell, 2006, Kwon and Montell, 2006)
Cytology
Description

Excision of P{EPgy2}lazaEY04417 results in an approximate 1.1kb deletion in laza (-317 to +1381).

(Kwon and Montell, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      laza1 mutants do not have the ability to discriminate between 18[o]C and temperatures between 20-24[o]C. The ability to choose 18[o]C over temperatures in the 14-16 and 26-32[o]C ranges is not impaired.

      (Kwon et al., 2008)

      7-day old laza1 mutant adults do not display retinal degeneration. Older flies (>15 days) exhibit light dependent retinal degeneration.

      (Kwon and Montell, 2006)

      laza1 mutant eyes display aberrant phototransduction. Exposure of wild-type flies to light results in a corneal negative receptor potential, which decays to baseline after cessation of the light stimulus. The amplitude of the light response is reduced nearly 3-fold in laza1 flies. The decreased phototransduction response in laza1 flies is not age dependent.

      laza1 flies exhibit a defect in the maximum light response in the mutant. The amplitude of the laza1 response to an increase in light increases less sharply than in wild-type.

      Termination of the photoresponse is approximately 4-fold faster in laza1 flies than in wild-type. Even with wild-type flies being exposed to a lower light intensity (so the electroretinogram response amplitude is the same), the laza1 flies exhibit a 2-fold quicker speed of termination of the photoresponse compared to wild-type.

      (Kwon and Montell, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      laza1 is a suppressor of abnormal neurophysiology phenotype of rdgA1

      (Kwon and Montell, 2006)
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      laza1, Scer\GAL4unspecified is a suppressor | partially of rhabdomere phenotype of PldUAS.cLa, Scer\GAL4unspecified

      (Kwon and Montell, 2006)

      laza1, Scer\GAL4unspecified is a suppressor | partially of eye phenotype of PldUAS.cLa, Scer\GAL4unspecified

      (Kwon and Montell, 2006)

      laza1 is a suppressor of rhabdomere phenotype of rdgA1

      (Kwon and Montell, 2006)

      laza1 is a suppressor of eye phenotype of rdgA1

      (Kwon and Montell, 2006)
      NOT Suppressor of
      Statement
      Reference

      laza1 is a non-suppressor of retina | somatic clone phenotype of Pect29, Scer\FLP1ey.PU

      (Zhao and Wang, 2020)

      laza1 is a non-suppressor of eye photoreceptor cell | somatic clone | decreased number phenotype of Pect29, Scer\FLP1ey.PU

      (Zhao and Wang, 2020)

      laza1 is a non-suppressor of rhabdomere | somatic clone | decreased number phenotype of Pect29, Scer\FLP1ey.PU

      (Zhao and Wang, 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Retinal degeneration is significantly reduced in 2-day-old PldScer\UAS.La (Scer\GAL4unspecified) ; laza1 flies relative to PldScer\UAS.La (Scer\GAL4unspecified flies. Suppression is detected in 3-day-old flies, however, by 7 days post-eclosion, the differences between PldScer\UAS.La (Scer\GAL4unspecified and PldScer\UAS.La (Scer\GAL4unspecified ; laza1 flies are not significant.

      (Kwon and Montell, 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      laza1 is rescued by laza+t10.35

      (Kwon et al., 2008)

      laza1 is rescued by laza+t10.35

      (Kwon and Montell, 2006)
      Comments

      The presence of laza+t.10.35kb in laza1 significantly rescues the ability to discriminate between 18 and 24[o]C.

      (Kwon et al., 2008)

      Introduction of the laza+t.10.35kb transgene restores the deactivation kinetics of laza1 mutants to wild-type levels.

      (Kwon and Montell, 2006)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      laza1
      (Zhao and Wang, 2020, Kwon et al., 2008, Kwon and Montell, 2006, Kwon and Montell, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)