FB2025_01 , released February 20, 2025
Allele: Dmel\cosCSBD.UAS.Tag:HA
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General Information
Symbol
Dmel\cosCSBD.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0197324
Feature type
allele
Associated gene
Dmel\cos
Associated Insertion(s)
Carried in Construct
P{UAS-cos.HA-CSBD}
Key Links
Transgenic product class
inframe_deletion
(Ogden et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Ogden et al., 2006)
Mutagen
in vitro construct
(Ogden et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-cos.HA-CSBD}
Cytology
Description

UASt regulatory sequences drive expression of the carboxy-terminal smo protein binding domain (amino acids 1001-1201) of cos, which is tagged with Tag:HA.

(Ogden et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cos
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing cosCSBD.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ptc-559.1 have decreased spacing between veins L3 and L4 in the wing compared to wild-type controls. Proximal fusions of veins L3 and L4 are seen.

      (Ogden et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Enhancer of
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of cosCSBD.Scer\UAS.T:Ivir\HA1 and smodsRNA.Scer\UAS.WIZ under the control of Scer\GAL4ptc-559.1 results a near lethal phenotype. Escapers show a more severe wing vein L3 and L4 fusions and significantly decreased spacing between wing veins L3 and L4 compared to expression of either cosCSBD.Scer\UAS.T:Ivir\HA1 or smodsRNA.Scer\UAS.WIZ alone.

      (Ogden et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cosCSBD.Scer\UAS.T:Ivir\HA1
      cosCSBD.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)