FB2025_01 , released February 20, 2025
Allele: Dmel\unc-104UAS.RVB.GFP(S65T)
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General Information
Symbol
Dmel\unc-104UAS.RVB.GFP(S65T)
Species
D. melanogaster
Name
FlyBase ID
FBal0215324
Feature type
allele
Associated gene
Dmel\unc-104
Associated Insertion(s)
Carried in Construct
P{UAS-unc-104.GFP.RVB}
Also Known As
UAS-Unc104-GFP, UAS-Unc-104-GFP
Key Links
Transgenic product class
cDNA
(Barkus et al., 2008)
wild_type
(Barkus et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Barkus et al., 2008)
wild_type
(Barkus et al., 2008)
Mutagen
in vitro construct
(Barkus et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-unc-104.GFP.RVB}
Cytology
Description

UASt regulatory sequences drive expression of full-length unc-104 cDNA, which is tagged with GFP(S65T)

(Barkus et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
unc-104
Tagged with
GFP(S65T)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  Parkinson's disease 8
      modeled by Lrrk1
      (Inoshita et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Toll-6-D42/unc-104UAS.RVB.GFP(S65T) partially rescues unc-104O1.2/unc-104P350

      (Barkus et al., 2008)

      Scer\GAL4Toll-6-D42/unc-104UAS.RVB.GFP(S65T) partially rescues unc-104P350/unc-104O3.1

      (Barkus et al., 2008)
      Comments

      Expression of unc-104Scer\UAS.RVB.T:Avic\GFP-S65T in motorneurons, under the control of Scer\GAL4D42, partially rescues the lethality of unc-104O1.2/unc-104P350 and unc-104O3.1/unc-104P350 mutants. The rescued animals sometimes die at pharate adult stages and mature adults are behaviorally depressed.

      (Barkus et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      unc-104Scer\UAS.RVB.T:Avic\GFP-S65T
      unc-104UAS.RVB.GFP(S65T)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)