FB2025_01 , released February 20, 2025
Allele: Dmel\ApplUAS.Tag:HA
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General Information
Symbol
Dmel\ApplUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0221085
Feature type
allele
Associated gene
Dmel\Appl
Associated Insertion(s)
Carried in Construct
P{UAS-Appl.HA}
Key Links
Transgenic product class
cDNA
(Sone et al., 2009)
wild_type
(Sone et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Sone et al., 2009)
wild_type
(Sone et al., 2009)
Mutagen
in vitro construct
(Sone et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Appl.HA}
Cytology
Description

UASt regulatory sequences drive expression of the full-length Appl protein (from cDNA clone GH04413), which is tagged at the C-terminal end with three copies of the Tag:HA tag.

(Sone et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Appl
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal recessive spinocerebellar ataxia 21
      modeled by yataKE2.1
      (Sone et al., 2009)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of ApplScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu has no effect on central brain volume in adult flies.

      (Sone et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ApplUAS.Tag:HA/Scer\GAL4elav.PLu is a suppressor | partially of short lived phenotype of yataKE2.1

      (Sone et al., 2009)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      ApplUAS.Tag:HA/Scer\GAL4elav.PLu is a suppressor of supraesophageal ganglion phenotype of yataKE2.1

      (Sone et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of ApplScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu partially rescues the shortened lifespan of yataKE2.1 homozygotes.

      Expression of ApplScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4elav.PLu rescues the reduced central brain volume seen in 14 day old yataKE2.1 homozygous adults.

      (Sone et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ApplScer\UAS.T:Ivir\HA1
      ApplUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)