FlyBase Allele Report: Dmel\Sbds[KK102203]

General Information

Symbol

Dmel\Sbds^KK102203

Species

D. melanogaster

Name

FlyBase ID

FBal0231662

Feature type

allele

Associated gene

Dmel\Sbds

Associated Insertion(s)

Carried in Construct

P{KK102203}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK102203}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK102203

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Shwachman-Diamond syndrome

CEA

(Takai et al., 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

muscle cell of A1-7 lateral longitudinal muscle 1 | third instar larval stage, with Scer\GAL4^elav.PLu

(Takai et al., 2020)

NMJ bouton | third instar larval stage, with Scer\GAL4^elav.PLu

(Takai et al., 2020)

presynaptic active zone | increased number | third instar larval stage, with Scer\GAL4^elav.PLu

(Takai et al., 2020)

Detailed Description

Statement

Reference

Expression of Sbds^KK102203 under the control of Scer\GAL4^elav.PLu leads to shorter migration distances in third instar larval crawling assay (with larvae often turning instead of moving linearly).

Larvae expressing Sbds^KK102203 under the control of Scer\GAL4^elav.PLu exhibit lower learning index in the odor/taste learning assay.

Expression of Sbds^KK102203 under the control of Scer\GAL4^elav.PLu leads to progressively reduced climbing ability in adults.

Expression of Sbds^GD13961 under the control of Scer\GAL4^elav.PLu leads to an increase in the size of neuromuscular junctions, the length of branches and the number of active zones in muscle 4 synapses.

(Takai et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108945

P{KK102203}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG8549^KK102203

Sbds^KK102203

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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