FlyBase Allele Report: Dmel\Hpd[KK105686]

General Information

Symbol

Dmel\Hpd^KK105686

Species

D. melanogaster

Name

FlyBase ID

FBal0233721

Feature type

allele

Associated gene

Dmel\Hpd

Associated Insertion(s)

Carried in Construct

P{KK105686}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK105686}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK105686

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Belfiori-Carrasco et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased mortality during development | nutrition conditional, with Scer\GAL4^A58

(Kosakamoto et al., 2024)

some die during larval stage | nutrition conditional, with Scer\GAL4^A58

(Kosakamoto et al., 2024)

some die during P-stage | nutrition conditional, with Scer\GAL4^A58

(Kosakamoto et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of Hpd^KK105686 under the control of Scer\GAL4^elav-C155 has no significant effect in the adult locomotor capacity (in negative geotaxis assays) in 18 days old adults and has no obvious effect on the adult brain, as compared to controls.

(Belfiori-Carrasco et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hpd^KK105686, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Belfiori-Carrasco et al., 2017)

NOT Enhancer of

Statement

Reference

Hpd^KK105686, Scer\GAL4^elav-C155 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Belfiori-Carrasco et al., 2017)

Hpd^KK105686, Scer\GAL4^elav-C155 is a non-enhancer of abnormal size | adult stage phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Belfiori-Carrasco et al., 2017)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Hpd^KK105686, Scer\GAL4^elav-C155 is a non-enhancer of adult brain phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav-C155

(Belfiori-Carrasco et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of Hpd^KK105686 enhances the adult locomotion defects, but has no effect on the adult brain loss and vacuolization, induced by the expression of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)} under the control of Scer\GAL4^elav-C155.

(Belfiori-Carrasco et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v103482

P{KK105686}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG11796^KK105686

Hpd^KK105686

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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