FlyBase Allele Report: Dmel\stol[KK106795]

General Information

Symbol

Dmel\stol^KK106795

Species

D. melanogaster

Name

FlyBase ID

FBal0234495

Feature type

allele

Associated gene

Dmel\stol

Associated Insertion(s)

Carried in Construct

P{KK106795}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK106795}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK106795

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Heinrich and Ryglewski, 2020)

abnormal neuroanatomy | adult stage, with Scer\GAL4^Toll-6-D42

(Heinrich and Ryglewski, 2020)

abnormal neurophysiology | P-stage, with Scer\GAL4^GMR23H06

(Heinrich and Ryglewski, 2020)

abnormal neurophysiology | P-stage, with Scer\GAL4^Toll-6-D42

(Heinrich and Ryglewski, 2020)

viable, with Scer\GAL4^elav-C155

(Heinrich and Ryglewski, 2020)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of stol^KK106795 under the control of Scer\GAL4^elav-C155 (in combination with Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in climbing speed of adults.

Expression of stol^KK106795 under the control of Scer\GAL4^Toll-6-D42 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to broader action potential width in pupal dorsolongitudinal wing depressor muscle (DLM) motor neurons. It also leads to a decrease in the total dendritic length and in the number of branches of adult DLM.

Expression of stol^KK106795 under the control of Scer\GAL4^GMR23H06 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the dendritic Ca2[+] signal amplitude but an increase in the axonal dendritic Ca2[+] signal amplitude induced upon firing by somatic ramp current injection in pupal DLM motor neurons.

(Heinrich and Ryglewski, 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

stol^KK106795/Scer\GAL4^Toll-6-D42 is a suppressor | partially of abnormal neurophysiology | P-stage phenotype of Scer\GAL4^Toll-6-D42, stj^KK101267

(Heinrich and Ryglewski, 2020)

stol^KK106795/Scer\GAL4^GMR23H06 is a suppressor | partially of abnormal neurophysiology | P-stage phenotype of Scer\GAL4^GMR23H06, stj^KK101267

(Heinrich and Ryglewski, 2020)

Other

Statement

Reference

Scer\GAL4^GMR23H06, stj^JF01825, stol^KK106795 has abnormal neurophysiology | P-stage phenotype

(Heinrich and Ryglewski, 2020)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^GMR23H06, stol^KK106795 has dendrite | P-stage phenotype, non-enhanceable by stj^KK101267/Scer\GAL4^GMR23H06

(Heinrich and Ryglewski, 2020)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR23H06, stol^KK106795 has dendrite | P-stage phenotype, non-suppressible by stj^KK101267/Scer\GAL4^GMR23H06

(Heinrich and Ryglewski, 2020)

NOT Enhancer of

Statement

Reference

stol^KK106795/Scer\GAL4^GMR23H06 is a non-enhancer of dendrite | P-stage phenotype of Scer\GAL4^GMR23H06, stj^KK101267

(Heinrich and Ryglewski, 2020)

Suppressor of

Statement

Reference

stol^KK106795/Scer\GAL4^Toll-6-D42 is a suppressor | partially of muscle cell of leg depressor muscle | P-stage phenotype of Scer\GAL4^Toll-6-D42, stj^KK101267

(Heinrich and Ryglewski, 2020)

stol^KK106795/Scer\GAL4^Toll-6-D42 is a suppressor | partially of motor neuron | P-stage phenotype of Scer\GAL4^Toll-6-D42, stj^KK101267

(Heinrich and Ryglewski, 2020)

stol^KK106795/Scer\GAL4^GMR23H06 is a suppressor | partially of axon | P-stage phenotype of Scer\GAL4^GMR23H06, stj^KK101267

(Heinrich and Ryglewski, 2020)

stol^KK106795/Scer\GAL4^GMR23H06 is a suppressor | partially of motor neuron | P-stage phenotype of Scer\GAL4^GMR23H06, stj^KK101267

(Heinrich and Ryglewski, 2020)

NOT Suppressor of

Statement

Reference

stol^KK106795/Scer\GAL4^GMR23H06 is a non-suppressor of dendrite | P-stage phenotype of Scer\GAL4^GMR23H06, stj^KK101267

(Heinrich and Ryglewski, 2020)

Other

Statement

Reference

Scer\GAL4^GMR23H06, stj^JF01825, stol^KK106795 has motor neuron | P-stage phenotype

(Heinrich and Ryglewski, 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of stj^JF01825 and stol^KK106795 under the control of Scer\GAL4^GMR23H06 (in combination with a Dicer-2 transgene to enhance RNAi efficiency) leads to a reduction in the high voltage activated Ca2[+] current amplitudes in pupal motor neurons.

(Heinrich and Ryglewski, 2020)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108150

P{KK106795}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG4587^KK106795

stol^KK106795

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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