FB2025_01 , released February 20, 2025
Allele: Dmel\bsKK108659
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General Information
Symbol
Dmel\bsKK108659
Species
D. melanogaster
Name
FlyBase ID
FBal0235719
Feature type
allele
Associated gene
Dmel\bs
Associated Insertion(s)
Carried in Construct
P{KK108659}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108659}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108659
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of bsKK108659 under the control of Scer\GAL41151 affects the indirect flight muscles myofibrils (although correctly specified, the muscles show a low polymerized actin content), but not jump muscles, as compared to controls. Although indirect flight muscle myofibril diameter is comparable to controls during mid-pupal stage, it is severely decreased in adults, suggesting myofibrils fail to grow from pupae to adults; however, sarcomere length is normal in both pupae and adults; the myofibril growth defects is rescued by the co-expression of bsUAS.ORF.GW.Tag:HA, with the myofibrils becoming even greater in diameter than those of controls.

      (DeAguero et al., 2019)

      Expression of bsKK108659 under the control of Scer\GAL4Bx-MS1096 has no effect on male wing size or patterning.

      Expression of bsKK108659 under the control of Scer\GAL4Bx-MS1096 has no effect on female wing size or patterning.

      (Schertel et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      bsKK108659 is partially rescued by bsUAS.ORF.GW.Tag:HA/Scer\GAL41151

      (DeAguero et al., 2019)
      Comments

      The co-expression of bsUAS.ORF.GW.Tag:HA significantly improves the indirect flight muscles defects (actin content and myofibril diameter), but not the flight defects, induced by the expression of bsKK108659 under the control of Scer\GAL41151; and the rescued myofibrils become greater in diameter than those of controls.

      (DeAguero et al., 2019)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      bsKK108659
      bsKK
      (DeAguero et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)