FB2025_01 , released February 20, 2025
Allele: Dmel\Syt4S284A.UAS
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General Information
Symbol
Dmel\Syt4S284A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241918
Feature type
allele
Associated gene
Dmel\Syt4
Associated Insertion(s)
Carried in Construct
P{UAS-Syt4.S284A}
Key Links
Transgenic product class
missense_variant
(Barber et al., 2009)
polypeptide_post_translational_processing_variant
(Barber et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Barber et al., 2009)
polypeptide_post_translational_processing_variant
(Barber et al., 2009)
Mutagen
in vitro construct
(Barber et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Syt4.S284A}
Cytology
Description

Amino acid replacement: S284A.

(Barber et al., 2009)

UASt regulatory sequences drive expression of Syt4 coding sequence where the C2A Ca[2+] binding domain is mutated through an amino acid residue change (S284A) that obliterates the phosphorylation site.

(Barber et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Syt4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Syt4S284A.Scer\UAS post-synaptically under the control of Scer\GAL4Mhc.PW fails to promote synaptic growth.

      Overexpression of Syt4S284A.Scer\UAS post-synaptically under the control of Scer\GAL4Mhc.PW eliminates the ability of Syt4 to induce presynaptic release.

      (Barber et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Syt4S284A.UAS/Scer\GAL4Mhc.PW fails to rescue Df(3R)rn16/Syt4BA1

      (Barber et al., 2009)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Syt4S284A.Scer\UAS
      Syt4S284A.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)