FB2025_01 , released February 20, 2025
Allele: Dmel\Syt4S284A.UAS
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General Information
Symbol
Dmel\Syt4S284A.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0241918
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

Amino acid replacement: S284A.

UASt regulatory sequences drive expression of Syt4 coding sequence where the C2A Ca[2+] binding domain is mutated through an amino acid residue change (S284A) that obliterates the phosphorylation site.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Syt4S284A.Scer\UAS post-synaptically under the control of Scer\GAL4Mhc.PW fails to promote synaptic growth.

Overexpression of Syt4S284A.Scer\UAS post-synaptically under the control of Scer\GAL4Mhc.PW eliminates the ability of Syt4 to induce presynaptic release.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Syt4S284A.Scer\UAS
Syt4S284A.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)