FB2025_01 , released February 20, 2025
Allele: Dmel\Pi3K59FUAS.cJa
Open Close
General Information
Symbol
Dmel\Pi3K59FUAS.cJa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Juhasz
FlyBase ID
FBal0243864
Feature type
allele
Associated gene
Dmel\Pi3K59F
Associated Insertion(s)
Carried in Construct
P{UAS-Pi3K59F.J}
Also Known As
UAS-Vps34
Key Links
Transgenic product class
wild_type
(Juhász et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Juhász et al., 2008)
Mutagen
in vitro construct
(Juhász et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Pi3K59F.J}
Cytology
Description

UAS regulatory sequences drive expression of Pi3K59F.

(Juhász et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pi3K59F
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Pi3K59FScer\UAS.cJa under the control of Scer\GAL4Pxn.PS has little effect on the size of endolysosomes in primary hemocytes derived from third instar larvae.

      (Velichkova et al., 2010)

      Expression of Pi3K59FScer\UAS.cJa in fat-body cells under the control of Scer\GAL4Act5C.PP does not induce the formation of autophagosomes in fed animals. In starved animals, the presence of autophagosomes is observed in fat-body cells.

      (Juhász et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Pi3K59FScer\UAS.cJa and Atg6Scer\UAS.T:Hsap\MYC in fat-body cells under the control of Scer\GAL4Act5C.PP promotes the formation of autophagosomes, which is not observed when either line is expressed alone.

      Co-expression of Pi3K59FScer\UAS.cJa and ird1Scer\UAS.cWa in fat-body cells under the control of Scer\GAL4Act5C.PP promotes the formation of autophagosomes, which is not observed when either line is expressed alone.

      (Juhász et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Tub.PU/Pi3K59FUAS.cJa partially rescues Pi3K59FΔm22

      (O'Farrell et al., 2017)
      Comments

      The expression of Pi3K59FScer\UAS.cJa under the control of Scer\GAL4tub.PU almost fully rescues the follicular epithelium multi-layering exhibited by Pi3K59FΔm22 homozygous somatic clones.

      (O'Farrell et al., 2017)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Pi3K59FScer\UAS.cJa
      Pi3K59FUAS.cJa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Juhasz
      Secondary FlyBase IDs
        References (3)