FB2025_01 , released February 20, 2025
Allele: Dmel\AMPKαK56R.UAS
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General Information
Symbol
Dmel\AMPKαK56R.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0246372
Feature type
allele
Associated gene
Dmel\AMPKα
Associated Insertion(s)
Carried in Construct
P{UAS-AMPKα.K56R}
Key Links
Transgenic product class
missense_variant
(Bland et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bland et al., 2010)
Mutagen
in vitro construct
(Bland et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-AMPKα.K56R}
Cytology
Description

UASt regulatory sequences drive expression of a kinase dead form of AMPKα (contains the amino acid replacement K56R).

(Bland et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
AMPKα
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of LamCUAS.cSa and AMPKαK56R.UAS under the control of Scer\GAL4fln.IFM does not lead to any obvious indirect flight muscle, wing posture or flight defects.

      (Chandran et al., 2019)

      Ectopic expression of AMPKαK56R.Scer\UAS under the control of the Scer\GAL4elav-C155 driver does not restore the decreased number of neuromuscular junction boutons characteristic for the Trpml1 mutant third instar larvae.

      (Wong et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      AMPKαK56R.UAS/Scer\GAL4unspecified fails to rescue AMPKαΔ39

      (Bland et al., 2010)
      Comments

      Ubiquitous expression of SNF1AK56R.Scer\UAS fails to rescue the lethality of SNF1AΔ39 mutants.

      (Bland et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AMPKαK56R.Scer\UAS
      AMPKαK56R.UAS
      SNF1AK56R.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)