FlyBase Allele Report: Dmel\Toll-6[MI02127]

General Information

Symbol

Dmel\Toll-6^MI02127

Species

D. melanogaster

Name

FlyBase ID

FBal0256812

Feature type

allele

Associated gene

Dmel\Toll-6

Associated Insertion(s)

Mi{MIC}Toll-6^MI02127

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

Mi{MIC}Toll-6^MI02127

Cytology

Description

Allele components

Component

Use(s)

Inserted element

Also carries

integrase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:15,339,634..15,339,634 [+]

(Jetti et al., 2023, Kong et al., 2022, Casas-Tintó et al., 2017, McIlroy et al., 2013, Bellen, 2011.2.28)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

abnormal size | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

Phenotype Manifest In

axon | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

neuromuscular junction | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

presynaptic active zone | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

type I bouton | larval stage (with Df(3L)BSC578)

(Ulian-Benitez et al., 2017)

Detailed Description

Statement

Reference

The larval NMJ of Toll-6^MI02127/Df(3L)BSC578 transheterozygotes exhibit significant decreases in the number of type Ib boutons, in the axonal length, in the number of NMJ branch points and in the number of active zones.

(Ulian-Benitez et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Toll-6^MI02127/Df(3L)BSC578 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has abnormal size | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Suppressed by

Statement

Reference

Toll-6^MI02127/Df(3L)BSC578 has abnormal neuroanatomy | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has abnormal size | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Toll-6^MI02127/Df(3L)BSC578 has neuromuscular junction | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has type I bouton | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has presynaptic active zone | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has axon | larval stage phenotype, non-enhanceable by Df(3R)ED6361/kek6³⁵

(Ulian-Benitez et al., 2017)

Suppressed by

Statement

Reference

Toll-6^MI02127/Df(3L)BSC578 has neuromuscular junction | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has type I bouton | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has presynaptic active zone | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Toll-6^MI02127/Df(3L)BSC578 has axon | larval stage phenotype, suppressible by kek6^{UAS.mRFP(Unk)}/Scer\GAL4^Toll-6-D42

(Ulian-Benitez et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The NMJ defects of Toll-6^MI02127/Df(3L)BSC578 transheterozygotes (i.e. decreases in the number of type Ib boutons, in the axonal length, in the number of NMJ branch points and in the number of active zones) are not enhanced by kek6³⁵/Df(3R)ED6361 transheterozygosity but are significantly suppressed by the expression of kek6^{UAS.mRFP(Unk)} under the control of Scer\GAL4^Toll-6-D42.

(Ulian-Benitez et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

34467

y¹ w^*; Mi{MIC}Toll-6^MI02127/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Toll-6^MI02127

(Kong et al., 2022, Mishra et al., 2020, Bellen, 2011.2.28)

Toll-6^MIO2127

(Ulian-Benitez et al., 2017)

Toll-6MI02127

(McIlroy et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

Open Close