Allele Dmel\Stat92E^{M647H.Scer\UAS.T:Avic\GFP-EGFP}

General Information
Symbol	Dmel\Stat92E^{M647H.Scer\UAS.T:Avic\GFP-EGFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0260717
Feature type	allele	Associated gene	Dmel\Stat92E

Allele class
Mutagen	in vitro construct - amino acid replacement
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - amino acid replacement (Karsten et al., 2006)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: M647H. (Karsten et al., 2006) Dominant negative allele. (Karsten et al., 2006)
Carried in construct	P{UAS-Stat92E.EGFP.M647H} (Karsten et al., 2006, Copf et al., 2011)
Tagged with	T:Avic\GFP^EGFP (Karsten et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	memory defective \| adult stage \| RU486 conditional, with Scer\GAL4^{Mef2.247.Switch} (Copf et al., 2011) visible, with Scer\GAL4^ey.PU (Karsten et al., 2006)
Phenotype Manifest In
	eye, with Scer\GAL4^ey.PU (Karsten et al., 2006)
Detailed Description
	Statement Reference Expression of Stat92E[M647H.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[Mef2.247.Switch] specifically during the adult stage (in the presence of RU486) causes a striking defect in long term memory, without affecting anesthesia-resistant memory or short term memory. (Copf et al., 2011) Expression of Stat92E[M647H.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[ey.PU] results in roughening of the eye, a reduction in eye volume and a loss of ventral eye tissue. (Karsten et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Stat92E^{M647H.Scer\UAS.T:Avic\GFP-EGFP}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Karsten et al., 2006, Cell. Signal. 18(6): 819--829 Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E. [FBrf0189973]

Allele Dmel\Stat92EM647H.Scer\UAS.T:Avic\GFP-EGFP

Allele Dmel\Stat92E^{M647H.Scer\UAS.T:Avic\GFP-EGFP}