|Feature type||allele||Associated gene||Dmel\cmpy|
|Allele class||amorphic allele - molecular evidence, amorphic allele - genetic evidence|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by insertion|
|Caused by aberration|
|Phenotype Manifest In|
cmpy[Δ8] homozygous mutants are viable, although females are sterile. cmpy[Δ8] homozygotes do not exhibit defects in neuronal cell fate acquisition or axon guidance. cmpy[Δ8] homozygotes display a 52% increase in the number of boutons at neuromuscular junction (NMJ) 6/7 and a 57% increase in type I boutons at NMJ 4. cmpy[Δ8]/Df(3L)BSC452 larvae show a comparable phenotype. cmpy[Δ8] mutant boutons tend to be smaller than those of wild type. cmpy[Δ8] mutants display a 2.9-fold increase in the number of satellite boutons at NMJ 4. cmpy[Δ8] mutant NMJs contain more active zones, but the percentage increase is comparable to that in bouton number, such that the active zone density remain constant. The assembly of periactive zones appears normal.
|Phenotype Manifest In|
cmpyΔ8 has type I bouton | supernumerary | third instar larval stage phenotype, suppressible | partially by gbb1/gbb[+]
cmpyΔ8 has type I bouton | supernumerary | third instar larval stage phenotype, suppressible | partially by Mad[+]/Mad1
cmpyΔ8 has type I bouton | supernumerary | third instar larval stage phenotype, suppressible | partially by witA12/wit[+]
The neuromuscular junction expansion phenotype seen in cmpy[Δ8] mutants is partially suppressed when animals are also heterozygous for gbb, Mad or wit[A12]. wit[A12], cmpy[Δ8] double mutants show a 44% reduction in bouton number at neuromuscular junction 4, thereby phenocopying the neuromuscular junction undergrowth displayed by wit single mutants. Scer\GAL4[D42]-mediated expression of gbb[dsRNA.Scer\UAS.cBa] suppresses the neuromuscular junction expansion phenotype seen in cmpy[Δ8] mutants.
|Complementation & Rescue Data|
|Partially rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 2 )|