FB2025_01 , released February 20, 2025
Allele: Dmel\Myd88UAS.cMa
Open Close
General Information
Symbol
Dmel\Myd88UAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Marek
FlyBase ID
FBal0268419
Feature type
allele
Associated gene
Dmel\Myd88
Associated Insertion(s)
Carried in Construct
P{UAS-Myd88.FL}
Key Links
Transgenic product class
wild_type
(Marek and Kagan, 2012)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Marek and Kagan, 2012)
Mutagen
in vitro construct
(Marek and Kagan, 2012)
Progenitor genotype
Carried in construct
P{UAS-Myd88.FL}
Cytology
Description

UASt regulatory sequences drive expression of full-length Myd88 (nucleotides 1-1614).

(Marek and Kagan, 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Myd88
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Myd88Scer\UAS.cMa under the control of Scer\GAL4elav.PU results in increased number of eve-positive neurons in both larval and pupal abdominal ventral nerve cord (VNC) but also leads to increased number of apoptotic (Dcp-1-positive) cells in the pupal VNC compared to driver-only controls.

      (Foldi et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in cell death (number of Dcp-1-positive cells) observed in the ventral nerve cord of Myd88Scer\UAS.cMa-expressing pupae (with the Scer\GAL4elav.PU driver) is fully suppressed by co-expression of bskGD10555.

      (Foldi et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4hs.PU/Myd88UAS.cMa rescues Myd88c03881

      (Marek and Kagan, 2012)

      Scer\GAL4VP16.mat.αTub67C/Myd88UAS.cMa rescues Myd88c03881

      (Marek and Kagan, 2012)
      Comments

      Expression of Myd88Scer\UAS.cMa under the control of Scer\GAL4hs.PU rescues the susceptibility of Myd88c03881 flies to infection with either E. faecalis or S. epidermidis.

      Expression of Myd88Scer\UAS.cMa under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 restores female fertility in Myd88c03881 flies.

      (Marek and Kagan, 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Myd88Scer\UAS.cMa
      Myd88UAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Marek
      Secondary FlyBase IDs
        References (2)