FlyBase Allele Report: Dmel\hth[NIG.17117R]

General Information

Symbol

Dmel\hth^NIG.17117R

Species

D. melanogaster

Name

FlyBase ID

FBal0272522

Feature type

allele

Associated gene

Dmel\hth

Associated Insertion(s)

Carried in Construct

P{NIG.17117R}

Also Known As

hth-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Japanese National Institute of Genetics, 2012.5.21)

Mutagen

in vitro construct

(Japanese National Institute of Genetics, 2012.5.21)

Progenitor genotype

Carried in construct

P{NIG.17117R}

Cytology

Description

UASt regulatory sequences drive expression of a 500bp inverted repeat.

(Japanese National Institute of Genetics, 2012.5.21)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-17117R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates acute myeloid leukemia

modeled by Hsap\HOXA9::Hsap\NUP98^WT.UAS

(Gavory et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of hth^NIG.17117R, in combination with a Dicer-2 transgene to enhance RNAi efficiency, under the control of Scer\GAL4^insc-Mz1407 from early first instar stage, in combination with a Gal80[ts] transgene, does not prevent female-specific loss of larval terminal neuroblasts, compared to controls.

(Ghosh et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

hth^NIG.17117R, Scer\GAL4^ey.PH is a suppressor | partially of visible | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH

(Gavory et al., 2021)

hth^NIG.17117R, Scer\GAL4^ey.PH is a suppressor | partially of abnormal size | adult stage phenotype of Hsap\HOXA9::Hsap\NUP98^WT.UAS, Scer\GAL4^ey.PH