FlyBase Allele Report: Dmel\AnxB11[HMS01775]

General Information

Symbol

Dmel\AnxB11^HMS01775

Species

D. melanogaster

Name

FlyBase ID

FBal0278893

Feature type

allele

Associated gene

Dmel\AnxB11

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS01775}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS01775}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS01775

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis type 23

CEC

(Barnard et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis type 23

is ameliorated by Hsap\ANXA11^{G175R.UAS.Tag:MYC}

(Barnard et al., 2024)

is ameliorated by Hsap\ANXA11^{R235Q.UAS.Tag:MYC}

(Barnard et al., 2024)

is ameliorated by Hsap\ANXA11^UAS.Tag:MYC

(Barnard et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior, with Scer\GAL4^unspecified

(Barnard et al., 2024)

short lived, with Scer\GAL4^elav.PU

(Barnard et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

AnxB11^HMS01775, Scer\GAL4^elav.PU has short lived phenotype, suppressible by Hsap\ANXA11^UAS.Tag:MYC, Scer\GAL4^elav.PU

(Barnard et al., 2024)

AnxB11^HMS01775, Scer\GAL4^elav.PU has short lived phenotype, suppressible by Hsap\ANXA11^{G175R.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Barnard et al., 2024)

AnxB11^HMS01775, Scer\GAL4^elav.PU has short lived phenotype, suppressible by Hsap\ANXA11^{R235Q.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Barnard et al., 2024)

AnxB11^HMS01775, Scer\GAL4^unspecified has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\ANXA11^UAS.Tag:MYC, Scer\GAL4^unspecified

(Barnard et al., 2024)

NOT suppressed by

Statement

Reference

AnxB11^HMS01775, Scer\GAL4^unspecified has decreased rate of adult locomotory behavior phenotype, non-suppressible by Hsap\ANXA11^{G175R.UAS.Tag:MYC}, Scer\GAL4^unspecified

(Barnard et al., 2024)

AnxB11^HMS01775, Scer\GAL4^unspecified has decreased rate of adult locomotory behavior phenotype, non-suppressible by Hsap\ANXA11^{R235Q.UAS.Tag:MYC}, Scer\GAL4^unspecified

(Barnard et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

38311

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01775}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

AnxB11^HMS01775

Anxb11^HMS01775

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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