FB2025_01 , released February 20, 2025
Allele: Dmel\Mtmr6HMS01807
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General Information
Symbol
Dmel\Mtmr6HMS01807
Species
D. melanogaster
Name
FlyBase ID
FBal0278925
Feature type
allele
Associated gene
Dmel\Mtmr6
Associated Insertion(s)
Carried in Construct
P{TRiP.HMS01807}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ni et al., 2010.12.1)
Mutagen
in vitro construct
(Ni et al., 2010.12.1)
Progenitor genotype
Carried in construct
P{TRiP.HMS01807}
Cytology
Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-HMS01807
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mtmr6HMS01807 under the control of Scer\GAL4Cg.PA in third instar larval fat body leads to increased number of autophagosomes and autolysosomes.

      Expression of Mtmr6HMS01807 under the control of Scer\GAL4NP0001 in pupal enterocytes leads to large electron-poor vesicles throughout the cytoplasm.

      Expression of Mtmr6HMS01807 under the control of Scer\GAL4Act.PU in third instar larval fat body clones leads to more acidic organelles with increased lysosomal enzyme function (Magic red fluorescence).

      (Allen et al., 2020)

      The expression of CG3530HMS01807 under the control of Scer\GAL4SPARC-MI00329-GAL4 (and Dicer-2, for a more efficient RNAi) in the larval fat body induces defective secretion, including intracellular matrix material, as shown by the retention of both secr.GFP and Vkg.GFP.

      (Ke et al., 2018)

      Females heterozygous for CG3530HMS01807 and Scer\GAL4mat.αTub67C.T:Hsim\VP16 crossed to CG3530HMS01807 males results in: 78% hatching; non-maternal effect.

      (Sopko et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG3530HMS01807
      Mtmr6HMS01807
      Name Synonyms
      Secondary FlyBase IDs
        References (5)