FlyBase Allele Report: Dmel\tefu[HMS02790]

General Information

Symbol

Dmel\tefu^HMS02790

Species

D. melanogaster

Name

FlyBase ID

FBal0293430

Feature type

allele

Associated gene

Dmel\tefu

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS02790}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS02790}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS02790

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | spermatogenesis, with Scer\GAL4^nanos.PU

(Yang et al., 2021)

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

Phenotype Manifest In

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Sopko et al., 2014)

male germline stem cell | absent | adult stage, with Scer\GAL4^nanos.PU

(Yang et al., 2021)

Detailed Description

Statement

Reference

Females heterozygous for tefu^HMS02790 and Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} crossed to tefu^HMS02790 males results in: 6% hatching; egg/embryonic phenotype: "empty, segmentation defects, variable"; maternal effect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^nanos.PU, tefu^HMS02790 has decreased cell number | spermatogenesis phenotype, non-suppressible by Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

Enhancer of

Statement

Reference

Scer\GAL4^nanos.PU/tefu^HMS02790 is an enhancer of decreased cell number | adult stage | female | temperature conditional phenotype of Crei\I-CreI^hs.PR

(Ma et al., 2016)

Other

Statement

Reference

Crei\I-CreI^hs.PR, Scer\GAL4^nanos.PU, tefu^HMS02790 has decreased cell number | female | adult stage phenotype

(Ma et al., 2016)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^nanos.PU, tefu^HMS02790 has male germline stem cell | adult stage | absent phenotype, non-suppressible by Rtel1^HMS00770, Scer\GAL4^nanos.PU

(Yang et al., 2021)

Enhancer of

Statement

Reference

Scer\GAL4^nanos.PU/tefu^HMS02790 is an enhancer of female germline stem cell | adult stage | temperature conditional phenotype of Crei\I-CreI^hs.PR

(Ma et al., 2016)

Other

Statement

Reference

Crei\I-CreI^hs.PR, Scer\GAL4^nanos.PU, tefu^HMS02790 has female germline stem cell | adult stage phenotype

(Ma et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The loss of germline stem cells (GSCs) observed upon heat-shock induced expression of Crei\I-CreI^hs.PR (to introduce DNA damage) is further exacerbated by expression of tefu^HMS02790 under the Scer\GAL4^nos.PU driver.

Scer\GAL4^nos.PU>tefu^HMS02790;Crei\I-CreI^hs.PR flies have fewer GSCs per germarium than wild-type controls even without the induction of DNA damage by heat-shock.

(Ma et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

44073

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02790}attP40

NIG-Fly

HMS02790