FlyBase Allele Report: Dmel\wake[RNAi.UAS.2]

General Information

Symbol

Dmel\wake^RNAi.UAS.2

Species

D. melanogaster

Name

FlyBase ID

FBal0295780

Feature type

allele

Associated gene

Dmel\wake

Associated Insertion(s)

Carried in Construct

P{UAS-wake.RNAi.2}

Key Links

Transgenic product class

RNAi_reagent

(Liu et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Liu et al., 2014)

Mutagen

in vitro construct

(Liu et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-wake.RNAi.2}

Cytology

Description

UAS regulatory sequences drive expression of a miRNA targeted against wake.

(Liu et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

wake

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep, with Scer\GAL4^P2.4.Pdf

(Liu et al., 2014)

abnormal sleep, with Scer\GAL4^wake.4.5

(Liu et al., 2014)

abnormal sleep | adult stage, with Scer\GAL4^dimm-929

(Chaturvedi et al., 2022)

abnormal sleep | adult stage, with Scer\GAL4^P2.4.Pdf

(Chaturvedi et al., 2022)

decreased sleep | adult stage, with Scer\GAL4^dimm-929

(Chaturvedi et al., 2022)

decreased sleep | adult stage, with Scer\GAL4^P2.4.Pdf

(Chaturvedi et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing wake^{miRNA.Scer\UAS.2} under the control of either Scer\GAL4^wake.4.5 or Scer\GAL4^P2.4.Pdf show a significant increase in sleep latency compared to controls.

(Liu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^P2.4.Pdf, wake^RNAi.UAS.2 has decreased sleep | adult stage phenotype, non-enhanceable by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^P2.4.Pdf, wake^RNAi.UAS.2 has abnormal sleep | adult stage phenotype, non-enhanceable by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^dimm-929, wake^RNAi.UAS.2 has decreased sleep | adult stage phenotype, non-enhanceable by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^dimm-929, wake^RNAi.UAS.2 has abnormal sleep | adult stage phenotype, non-enhanceable by Gat^33-1

(Chaturvedi et al., 2022)

NOT suppressed by

Statement

Reference

Scer\GAL4^P2.4.Pdf, wake^RNAi.UAS.2 has decreased sleep | adult stage phenotype, non-suppressible by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^P2.4.Pdf, wake^RNAi.UAS.2 has abnormal sleep | adult stage phenotype, non-suppressible by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^dimm-929, wake^RNAi.UAS.2 has decreased sleep | adult stage phenotype, non-suppressible by Gat^33-1

(Chaturvedi et al., 2022)

Scer\GAL4^dimm-929, wake^RNAi.UAS.2 has abnormal sleep | adult stage phenotype, non-suppressible by Gat^33-1

(Chaturvedi et al., 2022)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

wake^RNAi.UAS.2

wake^{miRNA.Scer\UAS.2}

wake^miRNA.UAS.2

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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