FlyBase Allele Report: Dmel\Shal[UAS.cPa]

General Information

Symbol

Dmel\Shal^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Ping

FlyBase ID

FBal0316419

Feature type

allele

Associated gene

Dmel\Shal

Associated Insertion(s)

Carried in Construct

P{UAS-Shal.P}

Key Links

Transgenic product class

wild_type

(Ping et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Ping et al., 2015)

Mutagen

in vitro construct

(Ping et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-Shal.P}

Cytology

Description

UASt regulatory sequences drive expression of the Shal2 isoform.

(Ping et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Shal

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Shal^UAS.cPa

(Ping et al., 2015)

model of Alzheimer's disease

is ameliorated by Shal^UAS.cPa

(Ping et al., 2015)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Feng et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Shal^Scer\UAS.cPa under the control of Scer\GAL4^elav.PU has no effect on mushroom body neuron survival.

(Ping et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Shal^UAS.cPa, Scer\GAL4^Tab2-201Y is a suppressor of abnormal neuroanatomy phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^Tab2-201Y

(Ping et al., 2015)

Shal^UAS.cPa, Scer\GAL4^elav.PU is a suppressor of abnormal neurophysiology phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Ping et al., 2015)

Shal^UAS.cPa, Scer\GAL4^elav.PU is a suppressor of abnormal learning phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Ping et al., 2015)

Shal^UAS.cPa, Scer\GAL4^elav.PU is a suppressor of short lived phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^elav.PU

(Ping et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

Shal^UAS.cPa, Scer\GAL4^Tab2-201Y is a suppressor of Kenyon cell phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}, Scer\GAL4^Tab2-201Y

(Ping et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Shal^Scer\UAS.cPa suppresses the increased excitability seen in primary neurons that have been dissociated from late-gastrula stage embryos expressing Hsap\APP^{Aβ1-42.Scer\UAS.cIa} under the control of Scer\GAL4^elav.PU. The average current required to induce action potential firing is similar to controls.

Expression of Shal^Scer\UAS.cPa suppresses the learning defects seen in larvae expressing Hsap\APP^{Aβ1-42.Scer\UAS.cIa} pan-neuronally under the control of Scer\GAL4^elav.PU.

Expression of Shal^Scer\UAS.cPa suppresses the climbing defects and mushroom body neuron loss seen in flies expressing Hsap\APP^{Aβ1-42.Scer\UAS.cIa} under the control of Scer\GAL4^elav.PU to near wild type levels.

Expression of Shal^Scer\UAS.cPa suppresses the mushroom body neuron loss seen in flies expressing Hsap\APP^{Aβ1-42.Scer\UAS.cIa} specifically in the mushroom body under the control of Scer\GAL4^Tab2-201Y.

Expression of Shal^Scer\UAS.cPa slightly but significantly suppresses the reduction in lifespan seen when Hsap\APP^{Aβ1-42.Scer\UAS.cIa} is expressed under the control of Scer\GAL4^elav.PU.

(Ping et al., 2015)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Shal^Scer\UAS.cPa

Shal^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Ping

Secondary FlyBase IDs

References (2)

Report Sections

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