FlyBase Allele Report: Dmel\Nil[HMC06011]

General Information

Symbol

Dmel\Nil^HMC06011

Species

D. melanogaster

Name

FlyBase ID

FBal0322280

Feature type

allele

Associated gene

Dmel\Nil

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06011}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06011}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC06011

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Nandi et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Nil^HMC06011, Scer\GAL4^GMR.PF is an enhancer of visible | adult stage phenotype of Acn^UAS.cNa, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Suppressor of

Statement

Reference

Nil^HMC06011, Scer\GAL4^GMR.PF is a suppressor of visible | adult stage phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Nil^HMC06011, Scer\GAL4^GMR.PF is a suppressor of abnormal eye color phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Other

Statement

Reference

Acn^UAS.cNa, Nil^HMC06011, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype

(Nandi et al., 2022)

Phenotype Manifest In

Enhancer of

Statement

Reference

Nil^HMC06011, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Acn^UAS.cNa, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Suppressor of

Statement

Reference

Nil^HMC06011, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Nil^HMC06011 enhances the rough rough eye phenotype induced by the expression of Acn^UAS.cNa under the control of Scer\GAL4^GMR.PF, and leads to a small eye.

(Nandi et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

65115

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06011}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG6036^HMC06011

Nil^HMC06011

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close