FB2025_01 , released February 20, 2025
Allele: HPV18\E6V158A.UAS.Tag:MYC
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General Information
Symbol
HPV18\E6V158A.UAS.Tag:MYC
Species
A. Human papillomavirus type 18
Name
FlyBase ID
FBal0327419
Feature type
allele
Associated gene
HPV18\E6
Associated Insertion(s)
Carried in Construct
P{UAS-HPV18E6.V158A.MYC}
Transgenic product class
missense_variant
(Padash Barmchi et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Padash Barmchi et al., 2016)
Mutagen
in vitro construct
(Padash Barmchi et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-HPV18E6.V158A.MYC}
Cytology
Description

UASt regulatory sequences drive expression of HPV18\E6 cDNA with a point mutation that disrupts the PDZ binding motif (V158A), tagged with Tag:MYC.

(Padash Barmchi et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
HPV18\E6
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cervical cancer
      CEA with Hsap\UBE3AUAS.cRa, Ras85DV12.cUa.UAS
      (Padash Barmchi et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The co-expression of Ras85DV12.cUa.Scer\UAS, but not Nint.U.Scer\UAS, with HPV18\E6V158A.Scer\UAS.T:Hsap\MYC and Hsap\UBE3AScer\UAS.cRa under the control of Scer\GAL4GMR.PU leads to the migration of a considerable proportion of the expressing eye cells into distant pupal tissues (e.g. abdomen), as compared to controls.

      (Padash Barmchi et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HPV18\E6V158A.Scer\UAS.T:Hsap\MYC
      HPV18\E6V158A.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)