FB2025_01 , released February 20, 2025
Allele: Dmel\dpnRNAi.UAS
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General Information
Symbol
Dmel\dpnRNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0337833
Feature type
allele
Associated gene
Dmel\dpn
Associated Insertion(s)
Carried in Construct
P{UAS-dpn.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Reichardt et al., 2018)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Reichardt et al., 2018)
Mutagen
in vitro construct
(Reichardt et al., 2018)
Progenitor genotype
Carried in construct
P{UAS-dpn.RNAi}
Cytology
Description

UAS regulatory sequences (derived from the Walium20 vector) drive expression of a shRNA that targets dpn.

(Reichardt et al., 2018)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dpn
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The larval brain and adult brain tumor phenotypes (and metastatic capacity of xenografts into wild-type hosts) resulting from the expression of bratGD7073 under the combined control of Scer\GAL4wor.PA, Scer\GAL80ase.PN are strongly suppressed by the co-expression of dpnshRNA.Scer\UAS.

      (Reichardt et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dpnRNAi.UAS
      dpnshRNA.Scer\UAS
      dpnshRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)