FB2025_01 , released February 20, 2025
Allele: Dmel\Pex19ΔF7
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General Information
Symbol
Dmel\Pex19ΔF7
Species
D. melanogaster
Name
FlyBase ID
FBal0340471
Feature type
allele
Associated gene
Dmel\Pex19
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Bülow et al., 2018)
Mutagen
P-element activity
(Bülow et al., 2018)
Progenitor genotype
P{EPgy2}Pex19EY21383
(Bülow et al., 2018)
Cytology
Description

Imprecise excision of P{EPgy2}Pex19EY21383 results in deletion of most of Pex19.

(Bülow et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Zellweger syndrome
      CEA
      (Bülow et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pex19ΔF7 maternal-zygotic mutants die at the end of embryogenesis, whereas zygotic mutants survive longer; most larvae develop to pupae, only 20% reach adulthood, and most of them die during the first 24 h. Both Pex19ΔF7 maternal-zygotic mutant embryos and Pex19ΔF7 zygotic mutant larvae show less abundant peroxisomes and larger, ballon-shaped mitochondria, as compared to controls.

      Pex19ΔF7 mutant adults do not properly inflate their wings, show a significantly decreased climbing speed and show a significant increase in the number of apoptotic cells in the adult optic lobe, as compared to controls.

      (Bülow et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Pex19ΔF7 has partially lethal - majority die phenotype, suppressible by Hnf4[+]/Hnf4Δ33

      (Bülow et al., 2018)

      Pex19ΔF7 has abnormal size | embryonic stage phenotype, suppressible by Hnf4[+]/Hnf4Δ33

      (Bülow et al., 2018)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Pex19ΔF7 has mitochondrion | embryonic stage phenotype, suppressible by Hnf4[+]/Hnf4Δ33

      (Bülow et al., 2018)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The larger, ballon-shaped mitochondria observed in Pex19ΔF7 maternal-zygotic mutant embryos is suppressed by Hnf4Δ33 heterozygosity.

      (Bülow et al., 2018)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pex19ΔF7
      (Bülow et al., 2018, Sellin et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)