FB2025_01 , released February 20, 2025
Allele: Dmel\mahjUAS.Tag:MYC
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General Information
Symbol
Dmel\mahjUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0351275
Feature type
allele
Associated gene
Dmel\mahj
Associated Insertion(s)
Carried in Construct
P{UAS-mahj.Myc}
Key Links
Transgenic product class
wild_type
(Ly et al., 2019)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ly et al., 2019)
Mutagen
in vitro construct
(Ly et al., 2019)
Progenitor genotype
Carried in construct
P{UAS-mahj.Myc}
Cytology
Description

UAS regulatory sequences drive expression of wild-type mahj that is tagged at the N-terminal end with Tag:MYC.

(Ly et al., 2019)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mahj
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing mahjUAS.Tag:MYC under the control of Scer\GAL4insc-Mz1407 results in the early larval brain (6h after larval hatching) showing signs of premature neuroblast reactivation: neuroblasts show a significant increase in cell divisions (both DNA replication/EdU staining and Mitosis/phospho-H3) and show cellular processes less frequently than controls.

      (Ly et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mahjUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)