FB2025_01 , released February 20, 2025
Allele: Dmel\Nuak17289
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General Information
Symbol
Dmel\Nuak17289
Species
D. melanogaster
Name
FlyBase ID
FBal0360164
Feature type
allele
Associated gene
Dmel\Nuak
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Brooks et al., 2020)
Mutagen
ethyl methanesulfonate
(Brooks et al., 2020)
Progenitor genotype
Cytology
Description

Amino acid replacement coordinates refer to the Nuak RD isoform.

(Brooks et al., 2020)

Amino acid replacement: R829term.

(Brooks et al., 2020)

Nucleotide substitution: C?T.

(Brooks et al., 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Nuak17289 homozygotes exhibit reduced larval locomotion and elongated pupae with shorter spiracles and a failure in abdominal air bubble displacement.

      Nuak17289 homozygous larvae exhibit thinner and detached body wall muscles devoid of typical sarcomere patterning and F-actin labeled myofibrillar material in large regions; wider sarcomeres; disintegration of Z-disc structures; accumulation of damaged organelles; mitochondria with abnormal cristae and electron-dense protein aggregates.

      Nuak17289 homozygous ventral longitudinal muscle 3 is longer in second instar larvae but this increase in muscle length is no longer apparent in third instar larvae.

      Nuak17289 homozygotes exhibit increased mortality during development under starvation conditions.

      Nuak17289/Df(3R)BSC479 exhibit elongated pupae.

      (Brooks et al., 2020)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Nuak[+]/Nuak17289 is an enhancer of abnormal body size | P-stage phenotype of Atg8aGD4654, Scer\GAL4Mef2.PR

      (Brooks et al., 2020)
      Phenotype Manifest In
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      NOT Enhancer of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Nuak17289 is rescued by NuakUAS.RD/Scer\GAL4Mef2.PR

      (Brooks et al., 2020)
      Partially rescued by

      Nuak17289 is partially rescued by NuakE197K.UAS/Scer\GAL4Mef2.PR

      (Brooks et al., 2020)

      Nuak17289 is partially rescued by Scer\GAL4Mef2.PR/NuakK99R.UAS

      (Brooks et al., 2020)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      NUAKR829*
      (Zhao et al., 2023)
      NUAKl(3)17289
      (Brooks et al., 2020)
      Nuak17289
      l(3)17289
      (Brooks et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)