FlyBase Allele Report: Dmel\GluRIIA[Q615R]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\GluRIIA^Q615R

General Information

Symbol

Dmel\GluRIIA^Q615R

Species

D. melanogaster

Name

FlyBase ID

FBal0386882

Feature type

allele

Associated gene

Associated Insertion(s)

TI{TI}GluRIIA^Q615R

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

(Perry et al., 2022)

gene targeting by homologous recombination

(Perry et al., 2022)

Progenitor genotype

Associated Insertion(s)

TI{TI}GluRIIA^Q615R

Cytology

Description

Amino acid replacement: Q615R.

(Perry et al., 2022)

The Q615R mutation has been introduced into endogenous GluRIIA.

(Perry et al., 2022)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

(Han et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

GluRIIA^Q615R, GluRIIB^SP5 has abnormal neurophysiology | larval stage phenotype, enhanceable by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

Other

Statement

Reference

GluRIIA^Q615R, GluRIIB^SP5 has abnormal neurophysiology | larval stage phenotype

(Han et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

GluRIIA^Q615R, GluRIIB^SP5 has embryonic/larval neuromuscular junction | larval stage phenotype, enhanceable by Scer\GAL4^VGlut1-OK371/VGlut1^UAS.cDa

(Han et al., 2023)

Other

Statement

Reference

GluRIIA^Q615R, GluRIIB^SP5 has embryonic/larval neuromuscular junction | larval stage phenotype

(Han et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

GluRIIA^Q615R

(Han et al., 2023, Perry et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections