FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cytoplasmic pattern recognition receptor signaling pathway ID (Ontology) GO:0002753 (Gene Ontology)
Definition The series of molecular signals initiated by the binding of a ligand from another organism to a cytoplasmic pattern recognition receptor (PRR). PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.[ ISBN:0781735149 PubMed:15199967 PubMed:17328678 PubMed:18272355 PubMed:19531363 PubMed:21187438 ]
Also Known As "cytoplasmic pathogen receptor signaling pathway" ; "cytoplasmic pattern recognition receptor signalling pathway" ; "cytoplasmic PRR signaling pathway" (for all, see Synonyms field below)
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innate immune response-activating signaling pathway
 |__pattern recognition receptor signaling pathway__
intracellular signal transduction                   |
 |__intracellular receptor signaling pathway________|
                                                    cytoplasmic pattern recognition receptor signaling pathway  9 rec.
                                                     |__cGAS/STING signaling pathway 7 rec.
                                                     |__endolysosomal toll-like receptor signaling pathway
                                                     |   |__toll-like receptor 3 signaling pathway
                                                     |   |__toll-like receptor 7 signaling pathway
                                                     |   |__toll-like receptor 8 signaling pathway
                                                     |   |__toll-like receptor 9 signaling pathway
                                                     |   |__toll-like receptor 11 signaling pathway
                                                     |   |__toll-like receptor 12 signaling pathway
                                                     |   |__toll-like receptor 13 signaling pathway
                                                     |__endosomal pattern recognition receptor signaling pathway
                                                     |__inflammasome-mediated signaling pathway
                                                     |__MDA-5 signaling pathway
                                                     |__nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
                                                     |   |__nucleotide-binding oligomerization domain containing 1 signaling pathway
                                                     |   |__nucleotide-binding oligomerization domain containing 2 signaling pathway
                                                     |__RIG-I signaling pathway
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Is a pattern recognition receptor signaling pathway
intracellular receptor signaling pathway
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Synonyms
  • "cytoplasmic caspase-recruiting domain (CARD) helicase signaling pathway" NARROW[ PubMed:17328678 ]
    "cytoplasmic pathogen receptor signaling pathway" EXACT
    "cytoplasmic pattern recognition receptor signalling pathway" EXACT
    "cytoplasmic PRR signaling pathway" EXACT
    "cytosolic PAMP receptor signaling pathway" EXACT
    "cytosolic pattern recognition receptor signaling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-9645460 "Alpha-protein kinase 1 signaling pathway"