FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulation of intracellular signal transduction ID (Ontology) GO:1902531 (Gene Ontology)
Definition Any process that modulates the frequency, rate or extent of intracellular signal transduction.
Also Known As "regulation of intracellular signaling cascade" ; "regulation of intracellular signaling chain"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 regulation of intracellular signal transduction (all annotations which use CV term, excluding "NOT" statements)       9
     involved_in | regulation of intracellular signal transduction       9
Spanning Tree (Parents/Children)
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signal transduction
 |__regulation of signal transduction__
 |__intracellular signal transduction__|
regulation of cell communication       |
 |__regulation of signal transduction__|
regulation of signaling                |
 |__regulation of signal transduction__|
regulation of response to stimulus     |
 |__regulation of signal transduction__|
                                       regulation of intracellular signal transduction  445 rec.
                                        |__negative regulation of intracellular signal transduction 153 rec.
                                        |   |__negative regulation of calcium-mediated signaling(+)
                                        |   |__negative regulation of cAMP/PKA signal transduction 7 rec.
                                        |   |__negative regulation of canonical NF-kappaB signal transduction 3 rec.
                                        |   |__negative regulation of cell cycle checkpoint(+) 1 rec.
                                        |   |__negative regulation of cytoplasmic pattern recognition receptor signaling pathway(+)
                                        |   |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                        |   |__negative regulation of hippo signaling 51 rec.
                                        |   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                        |   |__negative regulation of intracellular steroid hormone receptor signaling pathway(+) 3 rec.
                                        |   |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                        |   |__negative regulation of MAPK cascade(+) 53 rec.
                                        |   |__negative regulation of nitric oxide mediated signal transduction(+)
                                        |   |__negative regulation of non-canonical NF-kappaB signal transduction
                                        |   |__negative regulation of peroxisome proliferator activated receptor signaling pathway
                                        |   |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 11 rec.
                                        |   |__negative regulation of phospholipase C/protein kinase C signal transduction
                                        |   |__negative regulation of phosphorelay signal transduction system(+)
                                        |   |__negative regulation of protein kinase C signaling
                                        |   |__negative regulation of retinoic acid receptor signaling pathway
                                        |   |__negative regulation of signal transduction by p53 class mediator(+) 2 rec.
                                        |   |__negative regulation of SMAD protein signal transduction 1 rec.
                                        |   |__negative regulation of small GTPase mediated signal transduction(+) 8 rec.
                                        |   |__negative regulation of SREBP signaling pathway(+)
                                        |   |__negative regulation of stress-activated protein kinase signaling cascade(+) 3 rec.
                                        |   |__negative regulation of thyroid hormone receptor signaling pathway
                                        |   |__negative regulation of TOR signaling(+) 23 rec.
                                        |   |__negative regulation of vitamin D receptor signaling pathway
                                        |__positive regulation of intracellular signal transduction 236 rec.
                                        |   |__positive regulation of calcium-mediated signaling(+) 7 rec.
                                        |   |__positive regulation of cAMP/PKA signal transduction
                                        |   |__positive regulation of canonical NF-kappaB signal transduction 6 rec.
                                        |   |__positive regulation of cell cycle checkpoint(+) 1 rec.
                                        |   |__positive regulation of cGAS/STING signaling pathway 2 rec.
                                        |   |__positive regulation of endoplasmic reticulum unfolded protein response(+)
                                        |   |__positive regulation of hippo signaling 44 rec.
                                        |   |__positive regulation of hypoxia-inducible factor-1alpha signaling pathway
                                        |   |__positive regulation of inflammasome-mediated signaling pathway(+)
                                        |   |__positive regulation of intracellular steroid hormone receptor signaling pathway(+) 6 rec.
                                        |   |__positive regulation of intrinsic apoptotic signaling pathway(+) 3 rec.
                                        |   |__positive regulation of MAPK cascade(+) 80 rec.
                                        |   |__positive regulation of MDA-5 signaling pathway
                                        |   |__positive regulation of nitric oxide mediated signal transduction(+)
                                        |   |__positive regulation of non-canonical NF-kappaB signal transduction 1 rec.
                                        |   |__positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                        |   |__positive regulation of peroxisome proliferator activated receptor signaling pathway
                                        |   |__positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 17 rec.
                                        |   |__positive regulation of phospholipase C/protein kinase C signal transduction
                                        |   |__positive regulation of phosphorelay signal transduction system
                                        |   |__positive regulation of protein kinase C signaling
                                        |   |__positive regulation of retinoic acid receptor signaling pathway
                                        |   |__positive regulation of RIG-I signaling pathway
                                        |   |__positive regulation of signal transduction by p53 class mediator(+) 2 rec.
                                        |   |__positive regulation of SMAD protein signal transduction 6 rec.
                                        |   |__positive regulation of small GTPase mediated signal transduction(+) 43 rec.
                                        |   |__positive regulation of SREBP signaling pathway(+) 1 rec.
                                        |   |__positive regulation of stress-activated protein kinase signaling cascade(+) 2 rec.
                                        |   |__positive regulation of thyroid hormone receptor signaling pathway
                                        |   |__positive regulation of toll-like receptor 3 signaling pathway
                                        |   |__positive regulation of toll-like receptor 7 signaling pathway
                                        |   |__positive regulation of toll-like receptor 8 signaling pathway
                                        |   |__positive regulation of toll-like receptor 9 signaling pathway(+)
                                        |   |__positive regulation of toll-like receptor 11 signaling pathway
                                        |   |__positive regulation of toll-like receptor 12 signaling pathway
                                        |   |__positive regulation of toll-like receptor 13 signaling pathway
                                        |   |__positive regulation of TOR signaling(+) 45 rec.
                                        |   |__positive regulation of vitamin D receptor signaling pathway
                                        |__regulation of calcium-mediated signaling 14 rec.
                                        |   |__negative regulation of calcium-mediated signaling(+)
                                        |   |__positive regulation of calcium-mediated signaling(+) 7 rec.
                                        |   |__regulation of calcineurin-mediated signaling(+) 6 rec.
                                        |   |__regulation of CAMKK-AMPK signaling cascade(+) 1 rec.
                                        |__regulation of cAMP/PKA signal transduction 7 rec.
                                        |   |__negative regulation of cAMP/PKA signal transduction 7 rec.
                                        |   |__positive regulation of cAMP/PKA signal transduction
                                        |__regulation of canonical NF-kappaB signal transduction 11 rec.
                                        |   |__negative regulation of canonical NF-kappaB signal transduction 3 rec.
                                        |   |__positive regulation of canonical NF-kappaB signal transduction 6 rec.
                                        |__regulation of cell cycle checkpoint 6 rec.
                                        |   |__negative regulation of cell cycle checkpoint(+) 1 rec.
                                        |   |__positive regulation of cell cycle checkpoint(+) 1 rec.
                                        |   |__regulation of DNA damage checkpoint(+) 2 rec.
                                        |   |__regulation of spindle checkpoint(+) 4 rec.
                                        |__regulation of cytoplasmic pattern recognition receptor signaling pathway 2 rec.
                                        |   |__negative regulation of cytoplasmic pattern recognition receptor signaling pathway(+)
                                        |   |__positive regulation of cGAS/STING signaling pathway 2 rec.
                                        |   |__regulation of inflammasome-mediated signaling pathway(+)
                                        |   |__regulation of MDA-5 signaling pathway(+)
                                        |   |__regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                        |   |__regulation of RIG-I signaling pathway(+)
                                        |   |__regulation of toll-like receptor 3 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 7 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 8 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 9 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 11 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 12 signaling pathway(+)
                                        |   |__regulation of toll-like receptor 13 signaling pathway(+)
                                        |__regulation of endoplasmic reticulum unfolded protein response 4 rec.
                                        |   |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                        |   |__positive regulation of endoplasmic reticulum unfolded protein response(+)
                                        |   |__regulation of ATF6-mediated unfolded protein response(+)
                                        |   |__regulation of IRE1-mediated unfolded protein response(+) 2 rec.
                                        |   |__regulation of PERK-mediated unfolded protein response(+)
                                        |__regulation of hippo signaling 94 rec.
                                        |   |__negative regulation of hippo signaling 51 rec.
                                        |   |__positive regulation of hippo signaling 44 rec.
                                        |__regulation of hypoxia-inducible factor-1alpha signaling pathway
                                        |   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                        |   |__positive regulation of hypoxia-inducible factor-1alpha signaling pathway
                                        |__regulation of intracellular steroid hormone receptor signaling pathway 10 rec.
                                        |   |__negative regulation of intracellular steroid hormone receptor signaling pathway(+) 3 rec.
                                        |   |__positive regulation of intracellular steroid hormone receptor signaling pathway(+) 6 rec.
                                        |   |__regulation of androgen receptor signaling pathway(+)
                                        |   |__regulation of ecdysone receptor signaling pathway(+) 9 rec.
                                        |   |__regulation of intracellular estrogen receptor signaling pathway(+)
                                        |   |__regulation of nuclear receptor-mediated glucocorticoid signaling pathway(+)
                                        |__regulation of intrinsic apoptotic signaling pathway 9 rec.
                                        |   |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                        |   |__positive regulation of intrinsic apoptotic signaling pathway(+) 3 rec.
                                        |   |__regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                        |   |__regulation of hypoxia-induced intrinsic apoptotic signaling pathway(+)
                                        |   |__regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 3 rec.
                                        |   |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                        |   |__regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                        |   |__regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway(+)
                                        |   |__regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(+) 2 rec.
                                        |__regulation of MAPK cascade 144 rec.
                                        |   |__negative regulation of MAPK cascade(+) 53 rec.
                                        |   |__positive regulation of MAPK cascade(+) 80 rec.
                                        |   |__regulation of ERK1 and ERK2 cascade(+) 47 rec.
                                        |   |__regulation of ERK5 cascade(+)
                                        |   |__regulation of JNK cascade(+) 72 rec.
                                        |   |__regulation of p38MAPK cascade(+) 2 rec.
                                        |   |__regulation of pheromone response MAPK cascade(+)
                                        |   |__regulation of stress-activated MAPK cascade(+) 4 rec.
                                        |__regulation of nitric oxide mediated signal transduction
                                        |   |__negative regulation of nitric oxide mediated signal transduction(+)
                                        |   |__positive regulation of nitric oxide mediated signal transduction(+)
                                        |   |__regulation of nitric oxide-cGMP mediated signal transduction(+)
                                        |__regulation of non-canonical NF-kappaB signal transduction 1 rec.
                                        |   |__negative regulation of non-canonical NF-kappaB signal transduction
                                        |   |__positive regulation of non-canonical NF-kappaB signal transduction 1 rec.
                                        |__regulation of peroxisome proliferator activated receptor signaling pathway
                                        |   |__negative regulation of peroxisome proliferator activated receptor signaling pathway
                                        |   |__positive regulation of peroxisome proliferator activated receptor signaling pathway
                                        |__regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 28 rec.
                                        |   |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 11 rec.
                                        |   |__positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 17 rec.
                                        |__regulation of phosphorelay signal transduction system
                                        |   |__negative regulation of phosphorelay signal transduction system(+)
                                        |   |__positive regulation of phosphorelay signal transduction system
                                        |   |__regulation of ethylene-activated signaling pathway(+)
                                        |__regulation of protein kinase C signaling
                                        |   |__negative regulation of protein kinase C signaling
                                        |   |__positive regulation of protein kinase C signaling
                                        |__regulation of retinoic acid receptor signaling pathway
                                        |   |__negative regulation of retinoic acid receptor signaling pathway
                                        |   |__positive regulation of retinoic acid receptor signaling pathway
                                        |__regulation of signal transduction by p53 class mediator 5 rec.
                                        |   |__negative regulation of signal transduction by p53 class mediator(+) 2 rec.
                                        |   |__positive regulation of signal transduction by p53 class mediator(+) 2 rec.
                                        |   |__regulation of DNA damage response, signal transduction by p53 class mediator(+) 3 rec.
                                        |   |__regulation of intrinsic apoptotic signaling pathway by p53 class mediator(+) 3 rec.
                                        |__regulation of SMAD protein signal transduction 8 rec.
                                        |   |__negative regulation of SMAD protein signal transduction 1 rec.
                                        |   |__positive regulation of SMAD protein signal transduction 6 rec.
                                        |__regulation of small GTPase mediated signal transduction 96 rec.
                                        |   |__negative regulation of small GTPase mediated signal transduction(+) 8 rec.
                                        |   |__positive regulation of small GTPase mediated signal transduction(+) 43 rec.
                                        |   |__regulation of ARF protein signal transduction(+) 9 rec.
                                        |   |__regulation of Rab protein signal transduction 16 rec.
                                        |   |__regulation of Rac protein signal transduction(+) 4 rec.
                                        |   |__regulation of Ral protein signal transduction 1 rec.
                                        |   |__regulation of Rap protein signal transduction 1 rec.
                                        |   |__regulation of Ras protein signal transduction(+) 33 rec.
                                        |   |__regulation of Rho protein signal transduction(+) 25 rec.
                                        |   |__regulation of septation initiation signaling(+)
                                        |   |__symbiont-mediated perturbation of host small GTPase-mediated signal transduction(+)
                                        |__regulation of SREBP signaling pathway 1 rec.
                                        |   |__negative regulation of SREBP signaling pathway(+)
                                        |   |__positive regulation of SREBP signaling pathway(+) 1 rec.
                                        |__regulation of stress-activated protein kinase signaling cascade 5 rec.
                                        |   |__negative regulation of stress-activated protein kinase signaling cascade(+) 3 rec.
                                        |   |__positive regulation of stress-activated protein kinase signaling cascade(+) 2 rec.
                                        |   |__regulation of stress-activated MAPK cascade(+) 4 rec.
                                        |__regulation of thyroid hormone receptor signaling pathway
                                        |   |__negative regulation of thyroid hormone receptor signaling pathway
                                        |   |__positive regulation of thyroid hormone receptor signaling pathway
                                        |__regulation of TOR signaling 67 rec.
                                        |   |__negative regulation of TOR signaling(+) 23 rec.
                                        |   |__positive regulation of TOR signaling(+) 45 rec.
                                        |   |__regulation of TORC1 signaling(+) 52 rec.
                                        |   |__regulation of TORC2 signaling(+) 4 rec.
                                        |__regulation of vitamin D receptor signaling pathway
                                            |__negative regulation of vitamin D receptor signaling pathway
                                            |__positive regulation of vitamin D receptor signaling pathway
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Synonyms
  • "regulation of intracellular protein kinase cascade" NARROW
    "regulation of intracellular signal transduction pathway" NARROW
    "regulation of intracellular signaling cascade" EXACT
    "regulation of intracellular signaling chain" EXACT
    "regulation of intracellular signaling pathway" RELATED
    "regulation of signal transduction via intracellular signaling cascade" RELATED
    "regulation of signal transmission via intracellular cascade" NARROW
Secondary IDs
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