FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term pattern recognition receptor signaling pathway ID (Ontology) GO:0002221 (Gene Ontology)
Definition The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.[ ISBN:0781735149 PubMed:15199967 ]
Also Known As "pathogen receptor signaling pathway" ; "pathogen receptor signalling pathway" ; "PRR signaling pathway"
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Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       3
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Relevant FlyBase reports
 Genes
 pattern recognition receptor signaling pathway (all annotations which use CV term, excluding "NOT" statements)       3
     involved_in | pattern recognition receptor signaling pathway       3
Spanning Tree (Parents/Children)
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activation of innate immune response__________
immune response-activating signaling pathway__|
                                              innate immune response-activating signaling pathway
                                               |__pattern recognition receptor signaling pathway  101 rec.
                                                   |__cell surface pattern recognition receptor signaling pathway 3 rec.
                                                   |   |__cell surface toll-like receptor signaling pathway(+) 2 rec.
                                                   |   |__toll-like receptor 1 signaling pathway
                                                   |__cytoplasmic pattern recognition receptor signaling pathway 9 rec.
                                                   |   |__cGAS/STING signaling pathway 7 rec.
                                                   |   |__endolysosomal toll-like receptor signaling pathway(+)
                                                   |   |__endosomal pattern recognition receptor signaling pathway
                                                   |   |__inflammasome-mediated signaling pathway
                                                   |   |__MDA-5 signaling pathway
                                                   |   |__nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway(+)
                                                   |   |__RIG-I signaling pathway
                                                   |__pathogen-associated molecular pattern receptor signaling pathway
                                                   |__peptidoglycan recognition protein signaling pathway 88 rec.
                                                   |__toll-like receptor signaling pathway
                                                       |__MyD88-dependent toll-like receptor signaling pathway(+)
                                                       |__MyD88-independent toll-like receptor signaling pathway(+)
                                                       |__TIRAP-dependent toll-like receptor signaling pathway(+)
                                                       |__toll-like receptor 21 signaling pathway
                                                       |__toll-like receptor TLR1:TLR2 signaling pathway
                                                       |__toll-like receptor TLR6:TLR2 signaling pathway
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Is a innate immune response-activating signaling pathway
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