FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of gene expression ID (Ontology) GO:0010629 (Gene Ontology)
Definition Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      73
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 Genes
 negative regulation of gene expression (all annotations which use CV term, excluding "NOT" statements)      73
     involved_in | negative regulation of gene expression      73
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negative regulation of biosynthetic process
 |__negative regulation of macromolecule biosynthetic process__
regulation of macromolecule biosynthetic process               |
 |__regulation of gene expression______________________________|
 |__negative regulation of macromolecule biosynthetic process__|
negative regulation of macromolecule metabolic process         |
 |__negative regulation of macromolecule biosynthetic process__|
                                                               negative regulation of gene expression  660 rec.
                                                                |__mRNA catabolic process 138 rec.
                                                                |   |__maternal mRNA clearance 3 rec.
                                                                |   |__mitochondrial mRNA catabolic process(+) 4 rec.
                                                                |   |__nuclear-transcribed mRNA catabolic process(+) 65 rec.
                                                                |   |__polyadenylation-dependent mRNA catabolic process(+)
                                                                |   |__polyuridylation-dependent mRNA catabolic process
                                                                |__mRNA destabilization 68 rec.
                                                                |   |__3'-UTR-mediated mRNA destabilization 5 rec.
                                                                |   |__miRNA-mediated gene silencing by mRNA destabilization 26 rec.
                                                                |   |__nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 26 rec.
                                                                |   |__piRNA-mediated gene silencing by mRNA destabilization(+) 12 rec.
                                                                |   |__polyadenylation-dependent mRNA catabolic process(+)
                                                                |   |__polyuridylation-dependent mRNA catabolic process
                                                                |   |__siRNA-mediated gene silencing by mRNA destabilization(+) 1 rec.
                                                                |   |__transposable element silencing by mRNA destabilization(+) 10 rec.
                                                                |__negative regulation of cytokine production 2 rec.
                                                                |   |__negative regulation of chemokine production(+)
                                                                |   |__negative regulation of connective tissue growth factor production
                                                                |   |__negative regulation of cytokine production involved in immune response(+) 1 rec.
                                                                |   |__negative regulation of cytokine production involved in inflammatory response
                                                                |   |__negative regulation of endothelin production
                                                                |   |__negative regulation of fibroblast growth factor production
                                                                |   |__negative regulation of glial cell-derived neurotrophic factor production
                                                                |   |__negative regulation of granulocyte macrophage colony-stimulating factor production
                                                                |   |__negative regulation of hepatocyte growth factor production
                                                                |   |__negative regulation of interleukin-1 production(+)
                                                                |   |__negative regulation of interleukin-2 production
                                                                |   |__negative regulation of interleukin-3 production
                                                                |   |__negative regulation of interleukin-4 production
                                                                |   |__negative regulation of interleukin-5 production
                                                                |   |__negative regulation of interleukin-6 production
                                                                |   |__negative regulation of interleukin-7 production
                                                                |   |__negative regulation of interleukin-8 production
                                                                |   |__negative regulation of interleukin-9 production
                                                                |   |__negative regulation of interleukin-10 production
                                                                |   |__negative regulation of interleukin-11 production
                                                                |   |__negative regulation of interleukin-12 production
                                                                |   |__negative regulation of interleukin-13 production
                                                                |   |__negative regulation of interleukin-15 production
                                                                |   |__negative regulation of interleukin-16 production
                                                                |   |__negative regulation of interleukin-17 production(+)
                                                                |   |__negative regulation of interleukin-18 production
                                                                |   |__negative regulation of interleukin-19 production
                                                                |   |__negative regulation of interleukin-20 production
                                                                |   |__negative regulation of interleukin-21 production
                                                                |   |__negative regulation of interleukin-22 production
                                                                |   |__negative regulation of interleukin-23 production
                                                                |   |__negative regulation of interleukin-24 production
                                                                |   |__negative regulation of interleukin-25 production
                                                                |   |__negative regulation of interleukin-26 production
                                                                |   |__negative regulation of interleukin-27 production
                                                                |   |__negative regulation of interleukin-32 production
                                                                |   |__negative regulation of interleukin-33 production
                                                                |   |__negative regulation of interleukin-34 production
                                                                |   |__negative regulation of interleukin-35 production
                                                                |   |__negative regulation of interleukin-37 production
                                                                |   |__negative regulation of macrophage colony-stimulating factor production(+)
                                                                |   |__negative regulation of transforming growth factor beta production(+)
                                                                |   |__negative regulation of tumor necrosis factor superfamily cytokine production(+)
                                                                |   |__negative regulation of type I interferon production(+)
                                                                |   |__negative regulation of type II interferon production
                                                                |   |__negative regulation of type III interferon production
                                                                |   |__negative regulation of vascular endothelial growth factor production
                                                                |__negative regulation of gene expression, epigenetic 217 rec.
                                                                |   |__heterochromatin formation(+) 213 rec.
                                                                |   |__negative regulation of gene expression via chromosomal CpG island methylation
                                                                |__negative regulation of miRNA processing 3 rec.
                                                                |   |__negative regulation of pre-miRNA processing 3 rec.
                                                                |   |__negative regulation of primary miRNA processing
                                                                |__negative regulation of oxytocin production
                                                                |__negative regulation of production of molecular mediator of immune response 20 rec.
                                                                |   |__negative regulation of antimicrobial peptide production(+) 19 rec.
                                                                |   |__negative regulation of cytokine production involved in immune response(+) 1 rec.
                                                                |   |__negative regulation of granzyme A production
                                                                |   |__negative regulation of granzyme B production
                                                                |   |__negative regulation of immunoglobulin production(+)
                                                                |__negative regulation of protein maturation 6 rec.
                                                                |   |__negative regulation of N-terminal peptidyl-lysine acetylation
                                                                |   |__negative regulation of N-terminal peptidyl-methionine acetylation
                                                                |   |__negative regulation of protein activation cascade(+) 5 rec.
                                                                |   |__negative regulation of protein processing(+) 1 rec.
                                                                |__negative regulation of RNA splicing 8 rec.
                                                                |   |__negative regulation of mRNA splicing, via spliceosome(+) 3 rec.
                                                                |__negative regulation of rRNA processing
                                                                |__negative regulation of snoRNA processing
                                                                |__negative regulation of translation 85 rec.
                                                                |   |__miRNA-mediated gene silencing by inhibition of translation 15 rec.
                                                                |   |__negative regulation of cytoplasmic translation(+) 5 rec.
                                                                |   |__negative regulation of mitochondrial translation(+)
                                                                |   |__negative regulation of oskar mRNA translation 9 rec.
                                                                |   |__negative regulation of translation in response to stress(+)
                                                                |   |__negative regulation of translational elongation(+) 2 rec.
                                                                |   |__negative regulation of translational fidelity
                                                                |   |__negative regulation of translational initiation(+) 14 rec.
                                                                |   |__negative regulation of translational termination
                                                                |   |__ribosome hibernation 1 rec.
                                                                |   |__siRNA-mediated gene silencing by inhibition of translation
                                                                |__negative regulation of tRNA processing
                                                                |__post-transcriptional gene silencing 211 rec.
                                                                |   |__global gene silencing by mRNA cleavage 3 rec.
                                                                |   |__regulatory ncRNA-mediated post-transcriptional gene silencing(+) 204 rec.
                                                                |   |__target-directed miRNA degradation 6 rec.
                                                                |__programmed DNA elimination
                                                                |   |__programmed DNA elimination by chromosome breakage
                                                                |   |__programmed DNA elimination by elimination of internal DNA segments
                                                                |__regulatory ncRNA-mediated gene silencing 263 rec.
                                                                |   |__co-transcriptional gene silencing by RNA interference machinery
                                                                |   |__regulatory ncRNA-mediated heterochromatin formation(+) 31 rec.
                                                                |   |__regulatory ncRNA-mediated post-transcriptional gene silencing(+) 204 rec.
                                                                |__transcriptional attenuation
                                                                |   |__transcriptional attenuation by ribosome
                                                                |__transposable element silencing 45 rec.
                                                                    |__transposable element silencing by heterochromatin formation(+) 29 rec.
                                                                    |__transposable element silencing by mRNA destabilization(+) 10 rec.
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Is a regulation of gene expression
negative regulation of macromolecule biosynthetic process
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Synonyms
  • "gene silencing" RELATED
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