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FB2026_01
,
released March 12, 2026
[94F1-94F1];[95A4-95A4];
A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
94F1;95A4
Breakpoint based on release 3 sequence coordinate from Parks et al., 2004 (FBrf0174230), converted to release 5 coordinate.
Df(3R)Exel6194/Df(3R)irk2B mutant flies are viable.
The amount of apoptosis seen in Df(3R)Exel6194/Df(3R)irk2B mutant wing discs is similar to wild type.
The wings from Df(3R)Exel6194/Df(3R)irk2B mutant flies show wing vein defects, including incomplete or branched posterior cross veins, incomplete L5 vein, bifurcations of L3 and L4 veins and wing bristle transformations. 39% of flies have held-out wings from hinge defects. Rare Df(3R)Exel6194/Df(3R)irk2B mutant wings are notched or smaller than wild type. The penetrance and severity of wing phenotypes are dependent both on sex and the temperature during development; the most severe phenotypes are seen in males raised at low temperatures, with 38% of male flies having wing defects at 25[o]C.
17% of heterozygous Df(3R)Exel6194 mutant males display wing vein defects.