FB2026_03 , released September 17, 2026
Allele: Dmel\Adh71k
Open Close
General Information
Symbol
Dmel\Adh71k
Species
D. melanogaster
Name
FlyBase ID
FBal0000310
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
natural population
(Gibson et al., 1990)
Progenitor genotype
Cytology
Description

Amino acid replacement: P214S.

(Eisses et al., 1994)

3 unique mutations in the untranslated regions: deletion of base G at position 580-581, single site mutation at position 1700-1701 and single base substitution at position 886. A nucleotide deletion in the adult intron and at the same site in one of the larval enhancer regions in the 5' flanking region is an insertion of 5 nucleotides associated with a single base deletion creating a palindromic structure. Amino acid replacement: K192T. Amino acid replacement: P214S.

(Eisses et al., 1990)

In common with several other natural population alleles the sequence includes the triplet TCC at nucleotide positions 1555-1557.

(Gibson et al., 1990)

Amino acid replacement: K192T. Amino acid replacement: P214S.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
M57239
AAA28330
M71284
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Mutant protein shows AdhS-like reaction kinetics and Km values.

    (Eisses et al., 1994)
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer

    Thorig.

    Comments
    Comments

    pI of protein: 6.4. Unlike AdhF, will oxidize dihydroorotic acid to orotic acid and sarcosine to glycine.

    The ability of Adh71k enzyme to oxidise aldehydes has been studied.

    (Eisses, 1989)

    Adh71k encodes a thermostable multifunctional allozyme.

    (Eisses et al., 1990)
    External Crossreferences and Linkouts ( 4 )
    Crossreferences
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Synonyms and Secondary IDs (2)
    Reported As
    Symbol Synonym
    Adh-71k
    (Eisses et al., 1994)
    Adh71k
    Name Synonyms
    Secondary FlyBase IDs
      References (12)